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Conditions for Purine Synthesis: Did Prebiotic Synthesis Occur at Low Temperatures?

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Journal Science
Specialty Science
Date 1966 Jul 1
PMID 5938419
Citations 41
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Abstract

The rate of polymerization of hydrogen cyanide to aminomalononitrile and the tetramer, diaminomalonodinitrile, is quadratic in the total cyanide concentration. Since the reactions form part of a plausible prebiotic purine synthesis and since they compete with hydrolysis, concentration of cyanide may have been important. This may be achieved usefully by cooling to separate out ice.

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