The Renal Response to Acid Loads in Metabolic Alkalosis; an Assessment of the Mechanisms Regulating Acid Excretion

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1966 Apr 1

PMID 5937027

Citations 11

Authors

R L TANNEN

H L Bleich

W B SCHWARTZ

Affiliations

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Citing Articles

Sodium Bicarbonate Toxicity: An Unusual Yet Potential Cause of Severe Metabolic Alkalosis.

Fontoura M, Fernandes L, Machado F, Almeida P, Pereira T Cureus. 2025; 17(1):e76949.

PMID: 39906443 PMC: 11793077. DOI: 10.7759/cureus.76949.

Renal regulation of acid-base equilibrium during chronic administration of mineral acid.

de Sousa R, Harrington J, Ricanati E, Shelkrot J, SCHWARTZ W J Clin Invest. 1974; 53(2):465-76.

PMID: 11344560 PMC: 301489. DOI: 10.1172/JCI107580.

Influence of steady-state alterations in acid-base equilibrium on the fate of administered bicarbonate in the dog.

Adrogue H, Brensilver J, Cohen J, Madias N J Clin Invest. 1983; 71(4):867-83.

PMID: 6300190 PMC: 436944. DOI: 10.1172/jci110841.

The effects of chronic hypoxemia on electrolyte and acid-base equilibrium: an examination of normocapneic hypoxemia and of the influence of hypoxemia on the adaptation to chronic hypercapnia.

Sapir D, Levine D, SCHWARTZ W J Clin Invest. 1967; 46(3):369-77.

PMID: 6023772 PMC: 297057. DOI: 10.1172/JCI105538.

The induction of metabolic alkalosis by correction of potassium deficiency.

Bleich H, TANNEN R, SCHWARTZ W J Clin Invest. 1966; 45(4):573-9.

PMID: 5937028 PMC: 292731. DOI: 10.1172/JCI105371.

References

SCHWARTZ W, JENSON R, RELMAN A . The disposition of acid administered to sodium-depleted subjects: the renal response and the role of the whole body buffers. J Clin Invest. 1954; 33(4):587-97. PMC: 1087274. DOI: 10.1172/JCI102930. View

EPSTEIN F, Kleeman C, LAMDIN E, RUBINI M . Studies of the antidiuresis of quiet standing: observations upon electrolyte and acid-base excretion during sulfate diuresis. J Clin Invest. 1956; 35(3):308-13. PMC: 438812. DOI: 10.1172/JCI103279. View

SCHWARTZ W, JENSON R, RELMAN A . Acidification of the urine and increased ammonium excretion without change in acid-base equilibrium: sodium reabsorption as a stimulus to the acidifying process. J Clin Invest. 1955; 34(5):673-80. PMC: 438675. DOI: 10.1172/JCI103117. View

SULLIVAN L, WILDE W, Malvin R . Renal transport sites for K, H and NH3. Effect of impermeant anions on their transport. Am J Physiol. 1960; 198:244-54. DOI: 10.1152/ajplegacy.1960.198.2.244. View

BANK N, SCHWARTZ W . The influence of anion penetrating ability on urinary acidification and the excretion of titratable acid. J Clin Invest. 1960; 39:1516-25. PMC: 441886. DOI: 10.1172/JCI104171. View

GULYASSY P, Van Ypersele De Strihou C, SCHWARTZ W . On the mechanism of nitrate-induced alkalosis. The possible role of selective chloride depletion in acid-base regulation. J Clin Invest. 1962; 41:1850-62. PMC: 291110. DOI: 10.1172/JCI104642. View

NEEDLE M, Kaloyanides G, SCHWARTZ W . THE EFFECTS OF SELECTIVE DEPLETION OF HYDROCHLORIC ACID ON ACID-BASE AND ELECTROLYTE EQUILIBRIUM. J Clin Invest. 1964; 43:1836-46. PMC: 441984. DOI: 10.1172/JCI105057. View

LOGSDON E . A method for the determination of ammonia in biological materials on the autoanalyzer. Ann N Y Acad Sci. 1960; 87:801-7. DOI: 10.1111/j.1749-6632.1960.tb23237.x. View

RELMAN A, Lennon E, LEMANN Jr J . Endogenous production of fixed acid and the measurement of the net balance of acid in normal subjects. J Clin Invest. 1961; 40:1621-30. PMC: 290854. DOI: 10.1172/JCI104384. View

10.

SARTORIUS O, ROEMMELT J, PITTS R, Calhoon D, Miner P . THE RENAL REGULATION OF ACID-BASE BALANCE IN MAN. IV. THE NATURE OF THE RENAL COMPENSATIONS IN AMMONIUM CHLORIDE ACIDOSIS. J Clin Invest. 1949; 28(3):423-39. PMC: 439618. DOI: 10.1172/JCI102087. View

11.

Polak A, HAYNIE G, Hays R, SCHWARTZ W . Effects of chronic hypercapnia on electrolyte and acid-base equilibrium. I. Adaptation. J Clin Invest. 1961; 40:1223-37. PMC: 290836. DOI: 10.1172/JCI104353. View

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LAUSON H, Thompson D . Effects in dogs of decrease in glomerular filtration rate on cation excretion during intravenous administration of unreabsorbable anions. Am J Physiol. 1958; 192(1):198-208. DOI: 10.1152/ajplegacy.1957.192.1.198. View

13.

ATKINS E, SCHWARTZ W . Factors governing correction of the alkalosis associated with potassium deficiency; the critical role of chloride in the recovery process. J Clin Invest. 1962; 41:218-29. PMC: 289216. DOI: 10.1172/JCI104473. View