Coding Properties of 7-methylguanine

Overview

Journal Science

Specialty Science

Date 1966 Sep 16

PMID 5917775

Citations 11

Authors

R C WILHELM

D B LUDLUM

Affiliations

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Abstract

The abnormal base, 7-methylguanine, has been introduced into copolymers of uridylic and guanylic acids by methylation under controlled conditions. The resulting methylated copolymers have a markedly decreased template activity for polypeptide synthesis in vitro due to steric effects of the 7-methyl groups. Contrary to expectation, these polymers do not permit incorporation of amino acids whose codons contain the bases uracil and adenine.

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