D B LUDLUM
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Explore the profile of D B LUDLUM including associated specialties, affiliations and a list of published articles.
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86
Citations
640
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Recent Articles
1.
Matijasevic Z, Precopio M, Snyder J, LUDLUM D
Carcinogenesis
. 2001 Apr;
22(4):661-4.
PMID: 11285203
DNA damage is thought to be the initial event that causes sulfur mustard (SM) toxicity, while the ability of cells to repair this damage is thought to provide a degree...
2.
LUDLUM D, Li Q, Matijasevic Z
IARC Sci Publ
. 2000 Jan;
(150):271-7.
PMID: 10626227
The chloroethylnitrosoureas react extensively with cellular DNA to produce a variety of DNA adducts, including a deoxycytidine-deoxyguanosine (dC-dG) cross-link that is clearly cytotoxic. It is now well established that O6-alkylguanine-DNA-alkyltransferase...
3.
Matijasevic Z, Snyder J, LUDLUM D
Oncol Res
. 1999 Jun;
10(11-12):605-10.
PMID: 10367942
Normal human fibroblasts grown in cell culture undergo a reversible growth arrest when incubated at 28 degrees C. During incubation at 28 degrees C, levels of p53 and p21 rise...
4.
Li Q, Laval J, LUDLUM D
Carcinogenesis
. 1997 May;
18(5):1035-8.
PMID: 9163692
Transfection of the Escherichia coli fpg gene into Chinese hamster ovary cells has been reported to enhance survival after exposure to aziridine (C. Cussac and F.Laval, 1996, Nucleic Acids Res.,...
5.
LUDLUM D
Cancer Invest
. 1997 Jan;
15(6):588-98.
PMID: 9412665
The chloroethylnitrosoureas were developed in a synthetic program that began with the observation that N-methyl-N'-nitro-N-nitrosoguanidine was an effective agent against L1210 cells. The antitumor activity of the chloroethylnitrosoureas is based...
6.
Matijasevic Z, Stering A, Niu T, LUDLUM D
Carcinogenesis
. 1996 Oct;
17(10):2249-52.
PMID: 8895496
The toxic effects of sulfur mustard have been attributed to DNA modification with the formation of 7-hydroxyethylthioethyl guanine, 3-hydroxyethylthioethyl adenine and the cross-link, di-(2-guanin-7-yl-ethyl)sulfide. To investigate the action of bacterial...
7.
Niu T, Matijasevic Z, Stering A, LUDLUM D
Chem Biol Interact
. 1996 Mar;
100(1):77-84.
PMID: 8599857
Since the toxicities of sulfur mustard are attributed to DNA alkylation, levels of DNA modification in exposed cells should correlate with the intensity of exposure. We have found that 32P-postlabeling...
8.
Yu D, Niu T, LUDLUM D
Proc Natl Acad Sci U S A
. 1994 Jul;
91(15):7232-6.
PMID: 8041772
Many antitumor agents, including the mustards, form N-7 deoxyguanosine adducts in DNA that are difficult to quantitate by the 32P-postlabeling procedure because of their instability. We have developed a method...
9.
LUDLUM D, HAGOPIAN M, Niu T, Yu D
Chem Biol Interact
. 1994 Apr;
91(1):39-49.
PMID: 8194124
Sulfur mustard is acutely toxic to the skin, eyes, and respiratory tract, and is considered carcinogenic to humans by the IARC. Since all of these toxicities are thought to be...
10.
Protection against chloroethylnitrosourea cytotoxicity by eukaryotic 3-methyladenine DNA glycosylase
Matijasevic Z, Boosalis M, Mackay W, Samson L, LUDLUM D
Proc Natl Acad Sci U S A
. 1993 Dec;
90(24):11855-9.
PMID: 8265637
A eukaryotic 3-methyladenine DNA glycosylase gene, the Saccharomyces cerevisiae MAG gene, was shown to prevent N-(2-chloroethyl)-N-nitrosourea toxicity. Disruption of the MAG gene by insertion of the URA3 gene increased the...