Correlation Between Growth Inhibition and the Binding of Various Penicillins and Cephalosporins to Staphylococcus Aureus

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1969 Aug 1

PMID 5808073

Citations 18

Authors

J R Edwards

J T Park

Affiliations

Soon will be listed here.

Abstract

The concentration of penicillin (or cephalosporin) required to achieve a given rate of binding to Staphylococcus aureus H correlates well with that required for inhibition of growth. This result suggests that the irreversible binding of penicillins and cephalosporins to cells is responsible for their biological activity.

Citing Articles

Multiple changes of penicillin-binding proteins in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

Hakenbeck R, Tarpay M, Tomasz A Antimicrob Agents Chemother. 1980; 17(3):364-71.

PMID: 7425601 PMC: 283792. DOI: 10.1128/AAC.17.3.364.

Resistance to penicillin in mutants of a penicillinase-negative organism, Staphylococcus aureus H.

Park J, GRIFFITH M, Stevenson I J Bacteriol. 1971; 108(3):1154-60.

PMID: 5139535 PMC: 247200. DOI: 10.1128/jb.108.3.1154-1160.1971.

Binding of radioactive benzylpenicillin to sporulating Bacillus cultures: chemistry and fluctuations in specific binding capacity.

Lawrence P, Rogolsky M, Hanh V J Bacteriol. 1971; 108(2):662-7.

PMID: 4942758 PMC: 247124. DOI: 10.1128/jb.108.2.662-667.1971.

Aspects of the mechanism of action of some cephalosporins.

Russell A, Fountain R J Bacteriol. 1971; 106(1):65-9.

PMID: 4928017 PMC: 248645. DOI: 10.1128/jb.106.1.65-69.1971.

Correlation between the binding of beta-lactam antibiotics to Staphylococcus aureus and their physical-chemical properties.

Retsema J, Ray V Antimicrob Agents Chemother. 1973; 2(3):173-80.

PMID: 4790555 PMC: 444286. DOI: 10.1128/AAC.2.3.173.

References

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