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Preliminary Investigations of a New Beta-adrenoceptive Receptor Blocking Drug, LB46, in Man

Overview
Journal Br J Pharmacol
Publisher Wiley
Specialty Pharmacology
Date 1969 Jun 1
PMID 5787671
Citations 20
Authors
R C Hill
P Turner
Affiliations
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Abstract

1. Preliminary studies in man of a new beta-adrenoceptive receptor blocking drug, DL-4-(2-hydroxy-3-isopropylaminopropoxy)-indole (LB46), are described.2. LB46, 0.5 mg by oral administration, appeared to be of similar potency to propranolol 20 mg in inhibiting isoprenaline-induced and exercise-induced tachycardia.3. In comparable beta-receptor blocking doses LB46 did not show the negative chronotropic property possessed by propranolol.

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References
1.
Hill R, Turner P . The effects of a new beta-adrenoceptive receptor blocking drug on heart rate in man. Br J Pharmacol Chemother. 1968; 32(3):663-70. PMC: 1570309. DOI: 10.1111/j.1476-5381.1968.tb00465.x. View