Plasma and Adipose Tissue Fatty Acids of Diabetic Children on Long-term Corn Oil Diets

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1969 Jan 1

PMID 5765017

Citations 3

Authors

E C Albutt

G W Chance

Affiliations

Soon will be listed here.

Abstract

A method is described to determine the fatty acid composition of small samples of subcutaneous adipose tissue, and of fasting plasma free fatty acids (FFA) and triglycerides. These analyses were carried out on samples from five normal children, six diabetic children consuming a standard diabetic diet, 17 diabetic children prescribed a diet rich in corn oil since diagnosis 4-7 years ago, and 2 brothers with familial hypercholesterolemia on a corn oil diet for 3 yr. The results obtained showed that: (1) The composition of adipose tissue triglycerides in the diabetic children on a standard diet was similar to that in the normal children. (2) The 17 diabetic children were consuming different quantities of corn oil. (3) There was a highly significant correlation between the percentage of linoleic acid present in adipose tissue and in the fasting plasma FFA fraction. It is therefore concluded that future assessments of the adherence of these diabetic children to their corn oil diet will be possible by examination of the fasting plasma FFA fraction, obviating the need for repeated adipose tissue biopsies. (4) The sum of the concentration of saturated and monounsaturated fatty acids of the same chain length in adipose tissue was similar to that in the fasting plasma FFA fraction, even though the proportions of individual acids were different in the two fractions.

Citing Articles

Control of hyperlipidaemia in juvenile diabetes. Standard and corn-oil diets compared over a period of 10 years.

Chance G, Albutt E, Edkins S Br Med J. 1969; 3(5671):616-8.

PMID: 5811679 PMC: 1984395. DOI: 10.1136/bmj.3.5671.616.

The fatty acid pattern of adipose tissue and liver triglycerides according to fat droplet size in liver parenchymal cells of diabetic subjects.

Singer P, Gnauck G, Honigmann G, Stolz P, SCHLIACK V, KETTLER L Diabetologia. 1974; 10(5):455-8.

PMID: 4375642 DOI: 10.1007/BF01221637.

The fatty acid pattern of triglycerides in liver, adipose tissue and serum of diabetics with hyperlipoproteinemia before and during clofibrate treatment.

Singer P, Gnauck G, Honigmann G, Thoelke H, Schliack Acta Diabetol Lat. 1978; 15(1-2):40-52.

PMID: 716769 DOI: 10.1007/BF02581006.

References

SWEENEY M, ETTELDORF J, THROOP L, TIMMA D, WRENN E . Diet and fatty acid distribution in subcutaneous fat and in the cholesterol-triglyceride fraction of serum of young infants. J Clin Invest. 1963; 42:1-9. PMC: 289243. DOI: 10.1172/JCI104685. View

KAYDEN H, Karmen A, Dumont A . ALTERATIONS IN THE FATTY ACID COMPOSITION OF HUMAN LYMPH AND SERUM LIPOPROTEINS BY SINGLE FEEDINGS. J Clin Invest. 1963; 42:1373-81. PMC: 289411. DOI: 10.1172/JCI104821. View

HALLGREN B, STENHAGEN S, Svanborg A, Svennerholm L . Gas chromatographic analysis of the fatty acid composition of the plasma lipids in normal and diabetic subjects. J Clin Invest. 1960; 39:1424-34. PMC: 293388. DOI: 10.1172/JCI104162. View

DAYTON S, Hashimoto S, PEARCE M . Adipose tissue linoleic acid as a criterion of adherence to a modified diet. J Lipid Res. 1967; 8(5):508-10. View

Lloyd J . Control of dietary fat in relation to diabetic complications in children. Proc Nutr Soc. 1966; 25(1):74-82. DOI: 10.1079/pns19660014. View

Johnston P, Roots B . A source of contamination in the ultramicro analysis of methyl esters of fatty acids by gas-liquid chromatography. J Lipid Res. 1964; 5(3):477-8. View

Salt H, Wolff O, NESTADT A, Lloyd J . Control of lipaemia in children with diabetes mellitus; the role of insulin and the effects of a diet rich in unsaturated fatty acids. Lancet. 1960; 1(7115):71-5. DOI: 10.1016/s0140-6736(60)92897-x. View

BOWYER D, LEAT W, Howard A, GRESHAM G . THE DETERMINATION OF THE FATTY ACID COMPOSITION OF SERUM LIPIDS SEPARATED BY THIN-LAYER CHROMATOGRAPHY; AND A COMPARISON WITH COLUMN CHROMATOGRAPHY. Biochim Biophys Acta. 1963; 70:423-31. DOI: 10.1016/0006-3002(63)90772-8. View

Lloyd J, FOSBROOKE A, Wolff O, Salt H . Effect of dietary corn oil on lipaemia in diabetic children. Lancet. 1962; 1(7243):1329-30. DOI: 10.1016/s0140-6736(62)92425-x. View

10.

Fredrickson D, GORDON Jr R . Transport of fatty acids. Physiol Rev. 1958; 38(4):585-630. DOI: 10.1152/physrev.1958.38.4.585. View

11.

KINSELL L . Prevention of vascular disease in the diabetic. Diabetes. 1955; 4(4):298-303. DOI: 10.2337/diab.4.4.298. View

12.

TRAISMAN H, NEWCOMB A, Sever J, HAMMES R . Blood lipid and protein levels in juvenile diabetes mellitus. Diabetes. 1960; 9:481-4. DOI: 10.2337/diab.9.6.481. View

13.

Goodman D, Shiratori T . Fatty acid composition of human plasma lipoprotein fractions. J Lipid Res. 1964; 5(3):307-13. View

14.

Holman R, CASTER W, WIESE H . ESTIMATION OF LINOLEATE INTAKE OF MEN FROM SERUM LIPID ANALYSIS. Am J Clin Nutr. 1964; 14:193-6. DOI: 10.1093/ajcn/14.4.193. View

15.

Hirsch J, Farquhar J, AHRENS Jr E, Peterson M, STOFFEL W . Studies of adipose tissue in man. A microtechnic for sampling and analysis. Am J Clin Nutr. 1960; 8:499-511. DOI: 10.1093/ajcn/8.4.499. View

16.

Hashim S, Asfour R . Tocopherol in infants fed diets rich in polyunsaturated fatty acids. Am J Clin Nutr. 1968; 21(1):7-14. DOI: 10.1093/ajcn/21.1.7. View

17.

Lloyd J, JUKES H . Diet rich in unsaturated fat. Lancet. 1961; 1(7172):312-3. DOI: 10.1016/s0140-6736(61)91480-5. View

18.

DOLE V . A relation between non-esterified fatty acids in plasma and the metabolism of glucose. J Clin Invest. 1956; 35(2):150-4. PMC: 438791. DOI: 10.1172/JCI103259. View

19.

DAYTON S, Hashimoto S, Dixon W, PEARCE M . Composition of lipids in human serum and adipose tissue during prolonged feeding of a diet high in unsaturated fat. J Lipid Res. 1966; 7(1):103-11. View

20.

Folch J, Lees M, SLOANE STANLEY G . A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957; 226(1):497-509. View