» Articles » PMID: 5753556

Genetic Control of Drug Levels in Man: Phenylbutazone

Overview
Journal Science
Specialty Science
Date 1968 Mar 29
PMID 5753556
Citations 35
Authors
Affiliations
Soon will be listed here.
Abstract

Phenylbutazone was administered to seven pairs of identical (monozygotic) twins and to seven pairs of fraternal (dizygotic) twins. Individual half-lives ranged from 1.2 to 7.3 days. Subjects with identical genotypes (monozygotic twins) exhibited very similar phenylbutazone half-lives; significantly greater differences in half-life occurred in dizygotic twins. The previously established large variations among individuals in phenylbutazone metabolism appear to be genetically, rather than environmentally, determined.

Citing Articles

Pharmacogenetics in Italy: current landscape and future prospects.

Floris M, Moschella A, Alcalay M, Montella A, Tirelli M, Fontana L Hum Genomics. 2024; 18(1):78.

PMID: 38987819 PMC: 11234611. DOI: 10.1186/s40246-024-00612-w.


Precision Medicine in Kidney Transplantation: Just Hype or a Realistic Hope?.

Nobakht E, Jagadeesan M, Paul R, Bromberg J, Dadgar S Transplant Direct. 2021; 7(2):e650.

PMID: 33437865 PMC: 7793397. DOI: 10.1097/TXD.0000000000001102.


Novel genetic and epigenetic factors of importance for inter-individual differences in drug disposition, response and toxicity.

Lauschke V, Zhou Y, Ingelman-Sundberg M Pharmacol Ther. 2019; 197:122-152.

PMID: 30677473 PMC: 6527860. DOI: 10.1016/j.pharmthera.2019.01.002.


Pharmacogenetics, pharmacogenomics and ayurgenomics for personalized medicine: a paradigm shift.

Gupta P Indian J Pharm Sci. 2015; 77(2):135-41.

PMID: 26009644 PMC: 4442460. DOI: 10.4103/0250-474x.156543.


Saliva: diagnostics and therapeutic perspectives.

Spielmann N, Wong D Oral Dis. 2010; 17(4):345-54.

PMID: 21122035 PMC: 3056919. DOI: 10.1111/j.1601-0825.2010.01773.x.