Cellular Differentiation and the Aging Process in Cartilaginous Tissues. Mucopolysaccharide Synthesis in Cell Cultures of Chondrocytes

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1968 Dec 1

PMID 5688079

Citations 16

Authors

H J Shulman

K Meyer

Affiliations

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Abstract

Primary cell cultures of differentiated chondrocytes were shown to produce chondroitin-4-sulfate as the predominant mucopolysaccharide, with suggestive evidence for the synthesis of keratan sulfate and possibly chondroitin-6-sulfate. Chicken embryonic cartilage was shown to be composed mainly of chondroitin-4-sulfate, with a small amount of chondroitin-6-sulfate, but essentially no keratan sulfate. These findings were compared to the data of others, and a hypothesis explaining the aging process in cartilage in terms of cellular differentiation was presented.

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Behaviour of epiphyseal mouse chondrocyte populations in monolayer culture. Morphological and immunohistochemical studies.

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The loss of phenotypic traits by differentiated cells. VI. Behavior of the progeny of a single chondrocyte.

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Effect of 5-bromodeoxyuridine on expression of cultured chondrocytes grown in vitro.

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Hyaluronate in morphogenesis: inhibition of chondrogenesis in vitro.

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