Computed Action Potentials for Purkinje Fiber Membranes with Resistance and Capacitance in Series

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 1968 Aug 1

PMID 5661902

Citations 5

Authors

R E McAllister

Affiliations

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Abstract

The Hodgkin-Huxley equations, as modified by Noble for computation of Purkinje fiber action potentials, have been solved numerically for a membrane whose equivalent circuit contains a constant resistance in series with part of the capacitance. The rates of depolarization and repolarization of the computed action potential have thereby been brought into agreement with measured values. Possible explanations of the frequently observed pre-plateau notch and of fibrillatory activity arise. The effects of a time-dependent K conductance dependent on the second power of the parameter n, instead of the fourth, have also been considered.

Citing Articles

Computed membrane currents in cardiac Purkinje fibers during voltage clamps.

McAllister R Biophys J. 1969; 9(4):571-85.

PMID: 5778186 PMC: 1367537. DOI: 10.1016/S0006-3495(69)86404-0.

The frequency dependent character of the membrane capacity in cardiac Purkynĕ fibres.

Carmeliet E, Willems J J Physiol. 1971; 213(1):85-93.

PMID: 5575345 PMC: 1331724. DOI: 10.1113/jphysiol.1971.sp009369.

The electrical activity of canine cardiac Purkinje fibers in sodium-free, calcium-rich solutions.

Aronson R, Cranefield P J Gen Physiol. 1973; 61(6):786-808.

PMID: 4708407 PMC: 2203491. DOI: 10.1085/jgp.61.6.786.

Voltage clamp of cardiac muscle. A theoretical analysis of early currents in the single sucrose gap.

Kootsey J, Johnson E Biophys J. 1972; 12(11):1496-508.

PMID: 4642223 PMC: 1484190. DOI: 10.1016/S0006-3495(72)86177-0.

Reconstruction of the electrical activity of cardiac Purkinje fibres.

McAllister R, Noble D, Tsien R J Physiol. 1975; 251(1):1-59.

PMID: 1185607 PMC: 1348375. DOI: 10.1113/jphysiol.1975.sp011080.

References

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