Bone Marrow Origin of Immunologically Competent Lymphocytes in the Rat

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1968 May 1

PMID 5655104

Citations 9

Authors

D D McGregor

Affiliations

Soon will be listed here.

Abstract

Rat bone marrow is deficient in immunologically competent cells when compared with the peripheral pool of circulating small lymphocytes. However, circulating lymphocytes capable of initiating a lethal graft vs. host reaction can develop from myeloid precursors. In adult rats inoculated at birth with parental strain bone marrow cells, the thoracic duct lymph contains cells having the immunological capability of the marrow donor. The evidence suggests that immunologically competent lymphocytes derive from cells normally resident in bone marrow and probably not from precursors in the peripheral lymphocyte pool.

Citing Articles

Contribution of a thymic humoral factor to the development of an immunologically competent population from cells of mouse bone marrow.

Small M, Trainin N J Exp Med. 1971; 134(3 Pt 1):786-800.

PMID: 15776575 PMC: 2139066. DOI: 10.1084/jem.134.3.786.

Cells involved in the immune response. VI. The immune response to red blood cells in irradiated rabbits after administration of normal, primed, or immune allogeneic rabbit bone marrow cells.

Abdou N, Richter M J Exp Med. 1969; 129(4):757-74.

PMID: 5766947 PMC: 2138626. DOI: 10.1084/jem.129.4.757.

Blastogenic response of lymphocytes separated from bone marrow to allogeneic lymphoid cells in vitro.

Yoshida Y, OSMOND D Immunology. 1971; 21(5):767-79.

PMID: 5115610 PMC: 1408166.

Cells involved in the immune response. VII. The demonstration, using allotypic markers, of antibody formation by irradiation-resistant cells of irradiated rabbits injected with normal allogeneic bone marrow cells and sheep erythrocytes.

Richter M, Abdou N J Exp Med. 1969; 129(6):1261-73.

PMID: 4890861 PMC: 2138661. DOI: 10.1084/jem.129.6.1261.

Effect of tritiated thymidine and 5-bromodeoxyuridine on development of immunologically competent lymphocytes.

McGregor D Immunology. 1969; 16(1):83-90.

PMID: 4890409 PMC: 1409553.

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