Acetylcholine Binding to Torpedo Electroplax: Relationship to Acetylcholine Receptors

Overview

Journal Science

Specialty Science

Date 1971 Jul 23

PMID 5559905

Citations 7

Authors

M E Eldefrawi

A G Britten

A T Eldefrawi

Affiliations

Soon will be listed here.

Abstract

Binding of [(3)H]acetylcholine to a particulate fraction of Torpedo electroplax was measured by equilibrium dialysis. Two high-affinity sites present on phospholipoproteins bound acetylcholine reversibly, and binding was blocked by nicotinic drugs. Characteristics of this binding suggest that these phospholipoproteins may be acetylcholine receptors.

Citing Articles

Characterization and partial purification of the acetylcholine receptor from Torpedo electroplax.

Eldefrawi M, Eldefrawi A Proc Natl Acad Sci U S A. 1972; 69(7):1776-80.

PMID: 4505655 PMC: 426800. DOI: 10.1073/pnas.69.7.1776.

Macromolecules from lobster axon membranes that bind cholinergic ligands and local anesthetics (recpetors-procaine-acetylcholine-nicotine-Na + and K + gates).

Denburg J, Eldefrawi M, OBrien R Proc Natl Acad Sci U S A. 1972; 69(1):177-81.

PMID: 4500547 PMC: 427570. DOI: 10.1073/pnas.69.1.177.

Muscarinic cholinergic binding in rat brain.

Yamamura H, Snyder S Proc Natl Acad Sci U S A. 1974; 71(5):1725-9.

PMID: 4151898 PMC: 388311. DOI: 10.1073/pnas.71.5.1725.

Carbamylcholine and acetylcholine-sensitive, cation-selective ionophore as part of the purified acetylcholine receptor.

Shamoo A, Eldefrawi M J Membr Biol. 1975; 25(1-2):47-63.

PMID: 1214288 DOI: 10.1007/BF01868567.

Regulation of binding properties of the nicotinic receptor protein by cholinergic ligands in membrane fragments from Torpedo marmorata.

Weber M, Changeux J Proc Natl Acad Sci U S A. 1975; 72(9):3443-7.

PMID: 1059130 PMC: 433010. DOI: 10.1073/pnas.72.9.3443.