Effect of Iontophoretic Application of Cholinergic Agonists and Their Antagonists to Guinea-pig Pelvic Ganglia

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1971 Jan 1

PMID 5547760

Citations 7

Authors

M E Holman

T C Muir

J H Szurszewski

K Yonemura

Affiliations

Soon will be listed here.

Abstract

1. The electrical activity of guinea-pig pelvic ganglion cells following iontophoretically applied cholinergic drugs, alone and during orthodromic nerve stimulation via the hypogastric nerve, has been recorded intracellularly.2. Iontophoretic application of nicotine (Nic) and acetylcholine (ACh) reduced membrane resistance and caused a depolarization which in approximately 80% of cells led to the firing of action potentials. In the remainder, depolarization was unaccompanied by firing.3. Iontophoretic application of Nic and ACh reduced or abolished the amplitude of successively evoked orthodromic responses.4. ACh-induced depolarization, unlike that caused by tetanic stimulation, was not followed by a subsequent increase in the frequency of synaptic potentials.5. Di-hydrobetaerythroidine (DHbetaE) and atropine (Atr) inhibited the response to both orthodromic stimulation and iontophoretic application of Nic and ACh.6. There was no evidence for the existence of muscarinic receptors in guinea-pig pelvic ganglia. Iontophoretic application of muscarinic agonists alone and after tetanic stimulation of the hypogastric nerve produced no significant depolarization of the ganglion cell membrane.

Citing Articles

A study of the inferior mesenteric and pelvic ganglia of guinea-pigs with intracellular electrodes.

Crowcroft P, Szurszewski J J Physiol. 1971; 219(2):421-41.

PMID: 5158400 PMC: 1331639. DOI: 10.1113/jphysiol.1971.sp009670.

Pharmacological studies on the hypogastric ganglion of the rat and guinea-pig.

Bentley G Br J Pharmacol. 1972; 44(3):492-509.

PMID: 5040660 PMC: 1665817. DOI: 10.1111/j.1476-5381.1972.tb07286.x.

The effects of l,l-dimethyl-4-phenyl-piperazinium (DMPP) in the cat superior cervical ganglion in situ.

Haefely W Naunyn Schmiedebergs Arch Pharmacol. 1974; 281(1):57-91.

PMID: 4361144 DOI: 10.1007/BF00500612.

The effects of various "nicotine-like" agents in the cat superior cervical ganglion in situ.

Haefely W Naunyn Schmiedebergs Arch Pharmacol. 1974; 281(1):93-117.

PMID: 4273828 DOI: 10.1007/BF00500613.

Muscarinic postsynaptic events in the cat superior cervical ganglion in situ.

Haefely W Naunyn Schmiedebergs Arch Pharmacol. 1974; 281(2):119-43.

PMID: 4273717 DOI: 10.1007/BF00503494.

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