Alpha 2.0
Login Register
» Articles » PMID: 5432013

Induction and Repression of Amidase Enzymes in Aspergillus Nidulans

Overview
Journal J Bacteriol
Publisher American Society for Microbiology
Specialty Microbiology
Date 1970 Aug 1
PMID 5432013
Citations 22
Authors
M J Hynes
Affiliations
Soon will be listed here.
Abstract

Aspergillus nidulans can grow on acetamide as both a carbon and nitrogen source and can also grow on formamide as a nitrogen source. Two distinct enzymes, an acetamidase and a formamidase, are produced. The control of the synthesis of these two enzymes in a wild-type strain was investigated. The formamidase is induced by acetamide and formamide and repressed by ammonia. The acetamidase is induced by formamide and acetamide, repressed by carbon metabolites derived from glucose and acetate, and repressed by ammonia. Repression of the acetamidase by ammonia depends on the carbon source; growth on glucose but not on acetate or acetamide allows repression to occur. The pattern of acetamidase repression is compared with that of histidine catabolic enzymes in various bacteria.

Citing Articles

Nitrogen metabolite repression of metabolism and virulence in the human fungal pathogen Cryptococcus neoformans.

Lee I, Chow E, Morrow C, Djordjevic J, Fraser J Genetics. 2011; 188(2):309-23.

PMID: 21441208 PMC: 3122321. DOI: 10.1534/genetics.111.128538.

Glutamine Involvement in Nitrogen Control of Gibberellic Acid Production in Gibberella fujikuroi.

Munoz G, Agosin E Appl Environ Microbiol. 1993; 59(12):4317-22.

PMID: 16349128 PMC: 195903. DOI: 10.1128/aem.59.12.4317-4322.1993.

The formamidase gene of Aspergillus nidulans: regulation by nitrogen metabolite repression and transcriptional interference by an overlapping upstream gene.

Fraser J, Davis M, Hynes M Genetics. 2001; 157(1):119-31.

PMID: 11139496 PMC: 1461490. DOI: 10.1093/genetics/157.1.119.

Fungal catabolic gene regulation: molecular genetic analysis of the amdS gene of Aspergillus nidulans.

Davis M, Kelly J, Hynes M Genetica. 1993; 90(2-3):133-45.

PMID: 8119589 DOI: 10.1007/BF01435035.

Physiological characterization of a Neurospora crassa mutant with impaired regulation of nitrate reductase.

Premakumar R, SORGER G, Gooden D J Bacteriol. 1980; 144(2):542-51.

PMID: 6107286 PMC: 294701. DOI: 10.1128/jb.144.2.542-551.1980.

References
1.
Kinsky S, McELROY W . Neurospora nitrate reductase: the role of phosphate flavine and cytochrome c reductase. Arch Biochem Biophys. 1958; 73(2):466-83. DOI: 10.1016/0003-9861(58)90290-x. View
2.
Pateman J, REVER B, Cove D . Genetic and biochemical studies of nitrate reduction in Aspergillus nidulans. Biochem J. 1967; 104(1):103-11. PMC: 1270550. DOI: 10.1042/bj1040103. View
3.
Arst Jr H, Cove D . Methylammonium resistance in Aspergillus nidulans. J Bacteriol. 1969; 98(3):1284-93. PMC: 315326. DOI: 10.1128/jb.98.3.1284-1293.1969. View
4.
Apirion D . The two-way selection of mutants and revertants in respect of acetate utilization and resistance to fluoro-acetate in Aspergillus nidulans. Genet Res. 1965; 6(3):317-29. DOI: 10.1017/s0016672300004213. View
5.
Chasin L, MAGASANIK B . Induction and repression of the histidine-degrading enzymes of Bacillus subtilis. J Biol Chem. 1968; 243(19):5165-78. View