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Mixed Lymphocyte Cultures Produce Effector Cells: Model in Vitro for Allograft Rejection

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Journal Science
Specialty Science
Date 1970 Apr 3
PMID 5417055
Citations 34
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Abstract

Mouse peripheral lymphocytes sensitized in vitro by culturing with allogeneic lymphocytes produced immunospecific destruction of target cells, as measured by release of chromium-51. Thus the sensitizing and effector phases of the cell-bound immune response can both be studied in an in vitro system.

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