A Possible Structure of the Rabbit Reticulocyte Ribosome. An Exercise in Model Building

Overview

Journal Biochem J

Specialty Biochemistry

Date 1969 Oct 1

PMID 5343780

Citations 5

Authors

R A Cox

S A. Bonanou

Affiliations

Soon will be listed here.

Abstract

It is suggested that the location of each of the diverse ribosomal proteins in the ribosome, or in the ribosomal subparticles in their native or derived forms, is determined by the nucleotide sequence of the 16s and 23-30s RNA moieties, i.e. that the 16s and 23-30s RNA species provide a unique binding site for each species of ribosomal protein. The ways of assembling such a thread into a ribosome-like structure appear limited if the ribosome is largely stabilized by protein-protein interactions. The nucleoprotein thread was built into a structure, having the general features of a hollow cylinder, that is consistent with the known dimensions and properties of the rabbit reticulocyte ribosome. It appears possible to test the model by experiment.

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The effect of pancreatic ribonuclease on rabbit reticulocyte ribosomes and its interpretation in terms of ribosome structure.

Cox R Biochem J. 1969; 114(4):753-67.

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Asymmetry in the 50S ribosomal subunit of Escherichia coli.

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Primary sequence of the 16S ribosomal RNA of Escherichia coli.

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