Lymphocyte Transformation Test with Rabbit Liver Specific Lipoprotein (RLSP) in Chronic Active Hepatitis

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1979 Nov 1

PMID 527260

Citations 7

Authors

L ORTONA

V. Laghi

R Cauda

P Nervo

Affiliations

Soon will be listed here.

Abstract

Cellular sensitization to rabbit liver specific lipoprotein (RLSP) has been investigated using a lymphocyte transformation test in patients with chronic active hepatitis (CAH). A stimulation index greater than 2 was recorded in twenty out of twenty-five cases (eight of ten HBsAg positive and twelve of fiteen HBsAg negative) while values were lower than 2 in all the normal subjects. These results confirm the finding of sensitization to LSP in chronic active hepatitis irrespective of HBsAg status and show that rabbit LSP can be used as an alternative to the human antigen in the lymphocyte transformation test, and is further evidence that this liver membrane lipoprotein has antigenic determinants which have species-cross-reactivity.

Citing Articles

Histological and immunological investigation of liver-specific protein (LSP) immunized rabbits compared with patients with liver disease.

Feighery C, McDonald G, Greally J, Weir D Clin Exp Immunol. 1981; 45(1):143-51.

PMID: 7307345 PMC: 1537239.

Incidence of antibodies against rabbit liver specific lipoprotein (RLSP) in chronic active hepatitis.

ORTONA L, Laghi V, Tamburrini E, Troncone L, Bonifazi N, Nervo P Clin Exp Immunol. 1983; 52(2):437-40.

PMID: 6861379 PMC: 1535856.

Antibodies against human liver-specific protein (LSP) in acute and chronic viral hepatitis types A, B and non-A, non-B.

Meliconi R, Baraldini M, Stefanini G, Facchini A, Miglio F, Bortolotti F Clin Exp Immunol. 1981; 46(2):382-90.

PMID: 6802539 PMC: 1536384.

Study of cellular immunity in experimental autoimmune hepatitis in mice.

Mori Y, Mori T, Yoshida H, Ueda S, Iesato K, Wakashin Y Clin Exp Immunol. 1984; 57(1):85-92.

PMID: 6430615 PMC: 1536088.

Study of cellular immunity in experimental autoimmune hepatitis in mice: transfer of spleen cells sensitized with liver proteins.

Mori Y, Mori T, Ueda S, Yoshida H, Iesato K, Wakashin Y Clin Exp Immunol. 1985; 61(3):577-84.

PMID: 3878243 PMC: 1577267.

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