Alpha 2.0
Login Register
» Articles » PMID: 5272316

5-bromodeoxyuridine-induced Differentiation of a Neuroblastoma

Overview
Journal Proc Natl Acad Sci U S A
Specialty Science
Date 1970 Sep 1
PMID 5272316
Citations 38
Authors
D Schubert
F Jacob
Affiliations
Soon will be listed here.
Abstract

5-Bromodeoxyuridine induces the differentiation of mouse neuroblastoma C1300 to cells that morphologically resemble mature neurons. The induced differentiation can take place in the absence of DNA synthesis. This suggests that the halogenated pyrimidine need not be incorporated into DNA to alter the phenotype of the cell.

Citing Articles

The effects of 5-bromodeoxyuridine (BrdU) on morphogenesis of the early chick embryo.

Lee H, Deshpande A, Kalmus G Wilhelm Roux Arch Entwickl Mech Org. 2017; 174(1):102-106.

PMID: 28304738 DOI: 10.1007/BF00577060.

Bromodeoxyuridine induces senescence in neural stem and progenitor cells.

Ross H, Levkoff L, Marshall 2nd G, Caldeira M, Steindler D, Reynolds B Stem Cells. 2008; 26(12):3218-27.

PMID: 18802036 PMC: 4541772. DOI: 10.1634/stemcells.2008-0299.

Induction and inhibition of Friend erythroleukemia cell differentiation by pyrimidine analogs: analysis of the requirement for intracellular accumulation and incorporation into DNA.

Bilello J, GAURI K, Kuhne J, Warnecke G, Koch G Mol Cell Biol. 1982; 2(8):1020-4.

PMID: 7132967 PMC: 369890. DOI: 10.1128/mcb.2.8.1020-1024.1982.

Role of endogenous cat retrovirus in cell differentiation.

Rasheed S Proc Natl Acad Sci U S A. 1982; 79(23):7371-5.

PMID: 6961415 PMC: 347341. DOI: 10.1073/pnas.79.23.7371.

Membrane differentiation in human myeloid cells: expression of unique profiles of cell surface glycoproteins in myeloid leukemic cell lines blocked at different stages of differentiation and maturation.

Fukuda M, Koeffler H, Minowada J Proc Natl Acad Sci U S A. 1981; 78(10):6299-303.

PMID: 6947231 PMC: 349026. DOI: 10.1073/pnas.78.10.6299.

References
1.
Rotman B, PAPERMASTER B . Membrane properties of living mammalian cells as studied by enzymatic hydrolysis of fluorogenic esters. Proc Natl Acad Sci U S A. 1966; 55(1):134-41. PMC: 285766. DOI: 10.1073/pnas.55.1.134. View
2.
Bensch K, Malawista S . Microtubule crystals: a new biophysical phenomenon induced by Vinca alkaloids. Nature. 1968; 218(5147):1176-7. DOI: 10.1038/2181176a0. View
3.
Adelman M, Borisy G, Shelanski M, Weisenberg R, Taylor E . Cytoplasmic filaments and tubules. Fed Proc. 1968; 27(5):1186-93. View
4.
Lasher R, Cahn R . The effects of 5-Bromodeoxyuridine on the differentiation of chondrocytes in vitro. Dev Biol. 1969; 19(5):415-35. DOI: 10.1016/0012-1606(69)90080-3. View
5.
Bischoff R, Holtzer H . Inhibition of myoblast fusion after one round of DNA synthesis in 5-bromodeoxyuridine. J Cell Biol. 1970; 44(1):134-50. PMC: 2107791. DOI: 10.1083/jcb.44.1.134. View