Effect of P-nitromethylamphetamine on Biogenic Amines and Their Amino-acid Precursors in Rat Brain

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1971 Dec 1

PMID 5152025

Citations 1

Authors

B E Leonard

S A Shallice

Affiliations

Soon will be listed here.

Abstract

1. Low doses of p-nitromethylamphetamine caused small increases in the concentrations of brain noradrenaline and dopamine in the rat; a dose of 60 mg/kg however, caused a decrease in the concentrations of both amines. p-Nitromethylamphetamine caused behavioural hyperexcitability only at doses which approximated to half the LD50 (68 mg/kg).2. p-Nitromethylamphetamine potentiated the action of 4,alpha-dimethyl-m-tyramine in depleting brain noradrenaline. This suggests that it may affect brain noradrenaline concentrations by utilizing a reserpine resistant uptake mechanism.3. p-Nitromethylamphetamine decreased the concentration of brain 5-hydroxytryptamine.4. Changes in the blood and brain concentrations of tyrosine and gamma-amino-n-butyric acid concentration in the brain could not be correlated with the changes in brain amines. However, a rise in the concentration of brain tryptophan appeared to be correlated with the fall in brain 5-hydroxytryptamine.

Citing Articles

Some effects of the hallucinogenic drug 2, 5-dimethoxy-4-methyl amphetamine on the metabolism of biogenic amines in the rat brain.

Leonard B Psychopharmacologia. 1973; 32(1):33-49.

PMID: 4743235 DOI: 10.1007/BF00421706.

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