Immunological Behaviour Following Rubella Infection

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1979 Sep 1

PMID 509780

Citations 4

Authors

Y Niwa

T Kanoh

Affiliations

Soon will be listed here.

Abstract

Several immunological tests were performed on eighty-five patients with rubella. There was a decrease in total leucocytes, neutrophils and T cells, an increase in IgG and the complement components of C4, C9 and CH50, and a marked insensitivity to dinitrochlorobenzen (DNCB) and purified protein derivative (PPD) in many patients. Furthermore, atypical lymphocytes with lobulated nuclei, autoantibodies and reduced blastogenesis were found in some patients. These abnormal findings disappeared within 1 month. These marked immune abnormalities, although transient, may indicate an inhibition of DNA synthesis in lymphocytes which may have some bearing on the high incidence of embryopathy in pregnant women.

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References

CONE L, UHR J . IMMUNOLOGICAL DEFICIENCY DISORDERS ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA AND MULTIPLE MYELOMA. J Clin Invest. 1964; 43:2241-8. PMC: 289652. DOI: 10.1172/JCI105098. View

ROSENTHAL M, PISCIOTTA A, KOMNINOS Z, Goldenberg H, DAMESHEK W . The auto-immune hemolytic anemia of malignant lymphocytic disease. Blood. 1955; 10(3):197-227. View

Siegal F, Siegal M, GOOD R . Role of helper, suppressor and B-cell defects in the pathogenesis of the hypogammaglobulinemias. N Engl J Med. 1978; 299(4):172-8. DOI: 10.1056/NEJM197807272990404. View

Niwa Y, Kanoh T . Immune deficiency states and immune imbalance in systemic lupus erythematosus and other autoimmune diseases. Clin Immunol Immunopathol. 1979; 12(3):289-300. DOI: 10.1016/0090-1229(79)90032-1. View

Andrianakos A, Tsichlis P, Merikas E, Marketos S, Sharp J, Merikas G . Cell-mediated immunity in systemic lupus erythematosus. Clin Exp Immunol. 1977; 30(1):89-96. PMC: 1541176. View

Craddock P, HAMMERSCHMIDT D, White J, Dalmosso A, JACOB H . Complement (C5-a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostasis and leukopenia. J Clin Invest. 1977; 60(1):260-4. PMC: 372364. DOI: 10.1172/JCI108763. View

Nishioka K, Kawamura K, Hirayama T, Kawashima T, Shimada K . The complement system in tumor immunity: significance of elevated levels of complement in tumor bearing hosts. Ann N Y Acad Sci. 1976; 276:303-15. DOI: 10.1111/j.1749-6632.1976.tb41656.x. View

Alper C, Colten H, Rosen F, Rabson A, MACNAB G, Gear J . Homozygous deficiency of C3 in a patient with repeated infections. Lancet. 1972; 2(7788):1179-81. DOI: 10.1016/s0140-6736(72)92598-6. View

Lohrmann H, Novikovs L, Graw Jr R . Stimulatory capacity of human T and B lymphocytes in the mixed leukocyte culture. Nature. 1974; 250(462):144-6. DOI: 10.1038/250144a0. View

10.

Jondal M, Klein G . Surface markers on human B and T lymphocytes. II. Presence of Epstein-Barr virus receptors on B lymphocytes. J Exp Med. 1973; 138(6):1365-78. PMC: 2139459. DOI: 10.1084/jem.138.6.1365. View

11.

Pepys M, Butterworth A . Inhibition by C3 fragments of C3-dependent rosette formation and antigen-induced lymphocyte transformation. Clin Exp Immunol. 1974; 18(2):273-82. PMC: 1537889. View

12.

Tachibana T, Ishikawa M . A new micro-method for quantitation of human T- and B-lymphocytes. Jpn J Exp Med. 1973; 43(3):227-30. View

13.

Shimada K, Kogure M, Kawashima T, Nishioka K . Reduction of complement in Behçet's disease and drug allergy. Med Biol. 1974; 52(4):234-9. View

14.

Gyorkey F, Sinkovics J, Min K, Gyorkey P . A morphologic study on the occurrence and distribution of structures resembling viral nucleocapsids in collagen diseases. Am J Med. 1972; 53(2):148-58. DOI: 10.1016/0002-9343(72)90125-8. View

15.

Mancini G, Carbonara A, Heremans J . Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965; 2(3):235-54. DOI: 10.1016/0019-2791(65)90004-2. View

16.

Horwitz D, Cousar J . A relationship between impaired cellular immunity humoral suppression of lymphocyte function and severity of systemic lupus erythematosus. Am J Med. 1975; 58(6):829-35. DOI: 10.1016/0002-9343(75)90639-7. View

17.

DeHoratius R, Messner R . Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus. J Clin Invest. 1975; 55(6):1254-8. PMC: 301880. DOI: 10.1172/JCI108044. View

18.

Olson G, South M, GOOD R . Phytohaemagglutinin unresponsiveness of lymphocytes from babies with congenital rubella. Nature. 1967; 214(5089):695-6. DOI: 10.1038/214695a0. View

19.

Montgomery J, South M, Rawls W, Melnick J, Olson G, DENT P . Viral inhibition of lymphocyte response to phytohemagglutinin. Science. 1967; 157(3792):1068-70. DOI: 10.1126/science.157.3792.1068. View

20.

Alford Jr C . Studies on antibody in congenital rubella infections. I. Physicochemical and immunologic investigations of rubella neutralizing antibody. Am J Dis Child. 1965; 110(4):455-63. DOI: 10.1001/archpedi.1965.02090030475019. View