Decreased Oxygen Radical Generation by Neutrophils from Patients with Measles Presumably Owing to Activation of Suppressor T Lymphocytes

Overview

Journal J Clin Microbiol

Specialty Microbiology

Date 1985 Mar 1

PMID 3156875

Citations 1

Authors

Y Niwa

T Sakane

K Somiya

Y Miyachi

Affiliations

Soon will be listed here.

Abstract

The capacity for the generation of oxygen radicals by polymorphonuclear leukocytes (PMNs) was assessed in 29 patients with measles and in control groups. Patients with secondary bacterial infections showed a significantly decreased generation of oxygen radicals; this abnormality did not persist for more than 2 months after disease onset. Normal PMNs incubated with T lymphocytes from these measles patients generated significantly fewer oxygen radicals than those incubated with T cells from either control group. However, normal PMNs incubated with non-T lymphocytes from these measles patients produced normal oxygen radical levels. In addition, irradiation above 1,500 rads of T lymphocytes abrogated the suppressive effect of T cells on PMNs. On the other hand, these abnormal findings were not observed in patients with measles but without secondary bacterial infections. The secondary bacterial infections sometimes seen in measles patients may result from a decrease in oxygen radical generation, presumably induced by the suppressive activity of the T lymphocytes of the patients.

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References

Skosey J, Chow D, DAMGAARD E, Sorensen L . Effect of cytochalasin B on response of human polymorphonuclear leukocytes to zymosan. J Cell Biol. 1973; 57(1):237-40. PMC: 2108964. DOI: 10.1083/jcb.57.1.237. View

Niwa Y, Sakane T, Miyachi Y, Kanoh T, Somiya K . Decrease in generation of reactive oxygen species by neutrophils from patients with infectious mononucleosis: role of suppressor T lymphocytes. Blood. 1984; 64(5):994-9. View

Skosey J, DAMGAARD E, Chow D, Sorensen L . Modification of zymosan-induced release of lysosomal enzymes from human polymorphonuclear leukocytes by cytochalasin B. J Cell Biol. 1974; 62(3):625-34. PMC: 2109208. DOI: 10.1083/jcb.62.3.625. View

Siegal F, Siegal M . Enhancement by irradiated T cells of human plasma cell production: dissection of helper and suppressor functions in vitro. J Immunol. 1977; 118(2):642-7. View

Thorley-Lawson D, Chess L, Strominger J . Suppression of in vitro Epstein-Barr virus infection. A new role for adult human T lymphocytes. J Exp Med. 1977; 146(2):495-508. PMC: 2180764. DOI: 10.1084/jem.146.2.495. View

Reiss M, Roos D . Differences in oxygen metabolism of phagocytosing monocytes and neutrophils. J Clin Invest. 1978; 61(2):480-8. PMC: 372559. DOI: 10.1172/JCI108959. View

Tosato G, Magrath I, Koski I, Dooley N, Blaese M . Activation of suppressor T cells during Epstein-Barr-virus-induced infectious mononucleosis. N Engl J Med. 1979; 301(21):1133-7. DOI: 10.1056/NEJM197911223012101. View

Niwa Y, Kanoh T . Immunological behaviour following rubella infection. Clin Exp Immunol. 1979; 37(3):470-6. PMC: 1537775. View

Schooley R, Haynes B, Grouse J, Fauci A, Dolin R . Development of suppressor T lymphocytes for Epstein-Barr virus-induced B-lymphocyte outgrowth during acute infectious mononucleosis: assessment by two quantitative systems. Blood. 1981; 57(3):510-7. View

10.

Hirt A, Imbach P, Morell A, Wagner H . Infectious mononucleosis: sequential immunologic, cytochemical, and cytokinetic studies on single lymphoid cells in peripheral blood. Blood. 1981; 58(3):602-6. View

11.

SOLBERG C, Kalager T, Hill H, Glette J . Polymorphonuclear leukocyte function in bacterial and viral infections. Scand J Infect Dis. 1982; 14(1):11-8. DOI: 10.3109/inf.1982.14.issue-1.03. View

12.

Szigeti R, Masucci M, Henle W, Henle G, Purtilo D, Klein G . Effect of different Epstein-Barr virus-determined antigens (EBNA, EA, and VCA) on the leukocyte migration of healthy donors and patients with infectious mononucleosis and certain immunodeficiencies. Clin Immunol Immunopathol. 1982; 22(1):128-38. DOI: 10.1016/0090-1229(82)90029-0. View

13.

Niwa Y, Miyake S, Sakane T, Shingu M, Yokoyama M . Auto-oxidative damage in Behçet's disease--endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils. Clin Exp Immunol. 1982; 49(1):247-55. PMC: 1536650. View

14.

Niwa Y, Sakane T, Shingu M, Yokoyama M . Effect of stimulated neutrophils from the synovial fluid of patients with rheumatoid arthritis on lymphocytes--a possible role of increased oxygen radicals generated by the neutrophils. J Clin Immunol. 1983; 3(3):228-40. DOI: 10.1007/BF00915347. View

15.

Niwa Y, Sohmiya K . Enhanced neutrophilic functions in mucocutaneous lymph node syndrome, with special reference to the possible role of increased oxygen intermediate generation in the pathogenesis of coronary thromboarteritis. J Pediatr. 1984; 104(1):56-60. DOI: 10.1016/s0022-3476(84)80589-2. View

16.

Niwa Y, Sakane T, Kanoh T, Shichijo S, Wiederhold M, Yokoyama M . Transient autoantibodies with elevated complement levels in common viral diseases. J Clin Lab Immunol. 1984; 13(4):183-8. View

17.

Niwa Y, Sakane T, Shingu M, Yokoyama M . Role of stimulated neutrophils from patients with systemic lupus erythematosus in disturbed immunoreactivity, with special reference to increased oxygen intermediates generated by the neutrophils. J Clin Lab Immunol. 1984; 14(1):35-43. View

18.

Lohrmann H, Novikovs L, Graw Jr R . Stimulatory capacity of human T and B lymphocytes in the mixed leukocyte culture. Nature. 1974; 250(462):144-6. DOI: 10.1038/250144a0. View