Adaptation of Muscle to Exercise. Increase in Levels of Palmityl Coa Synthetase, Carnitine Palmityltransferase, and Palmityl Coa Dehydrogenase, and in the Capacity to Oxidize Fatty Acids

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1971 Nov 1

PMID 5096516

Citations 67

Authors

P A Mole

L B Oscai

J O Holloszy

Affiliations

Soon will be listed here.

Abstract

The capacity of gastrocnemius and quadriceps muscles to oxidize palmitate, oleate, linoleate, palmityl CoA, and palmityl carnitine doubled in rats subjected to a program of treadmill running. The rate of palmitate oxdation by whole homogenates of, or the mitochondrial fraction from, leg muscles was twice as great per gram wet weight of muscle in the trained as in the sedentary animals over a wide range (0.125-1.5 mM) of palmitate concentrations. The levels of activity of carnitine palmityltransferase, palmityl CoA dehydrogenase, and mitochondrial ATP-dependent palmityl CoA synthetase expressed per gram of muscle doubled in gastrocnemius and quadriceps muscles in response to the running program. The protein content of the mitochondrial fraction from these muscles was increased approximately 60%.

Citing Articles

Computational Analysis Reveals Unique Binding Patterns of Oxygenated and Deoxygenated Myoglobin to the Outer Mitochondrial Membrane.

Anishkin A, Adepu K, Bhandari D, Adams S, Chintapalli S Biomolecules. 2023; 13(7).

PMID: 37509174 PMC: 10377724. DOI: 10.3390/biom13071138.

Insulin and cancer: a tangled web.

Leitner B, Siebel S, Akingbesote N, Zhang X, Perry R Biochem J. 2022; 479(5):583-607.

PMID: 35244142 PMC: 9022985. DOI: 10.1042/BCJ20210134.

The Effect of a Single Bout of Exercise on Vitamin B2 Status Is Not Different between High- and Low-Fit Females.

Janssen J, Lagerwaard B, Nieuwenhuizen A, Timmers S, de Boer V, Keijer J Nutrients. 2021; 13(11).

PMID: 34836352 PMC: 8618623. DOI: 10.3390/nu13114097.

Effect of heat acclimation on metabolic adaptations induced by endurance training in soleus rat muscle.

Tardo-Dino P, Taverny C, Siracusa J, Bourdon S, Bauge S, Koulmann N Physiol Rep. 2021; 9(16):e14686.

PMID: 34405575 PMC: 8371354. DOI: 10.14814/phy2.14686.

Running and Swimming Differently Adapt the BDNF/TrkB Pathway to a Slow Molecular Pattern at the NMJ.

Just-Borras L, Cilleros-Mane V, Hurtado E, Biondi O, Charbonnier F, Tomas M Int J Mol Sci. 2021; 22(9).

PMID: 33925507 PMC: 8123836. DOI: 10.3390/ijms22094577.

References

Gollnick P, King D . Effect of exercise and training on mitochondria of rat skeletal muscle. Am J Physiol. 1969; 216(6):1502-9. DOI: 10.1152/ajplegacy.1969.216.6.1502. View

ISSEKUTZ Jr B, MILLER H, Paul P, RODAHL K . SOURCE OF FAT OXIDATION IN EXERCISING DOGS. Am J Physiol. 1964; 207:583-9. DOI: 10.1152/ajplegacy.1964.207.3.583. View

Paul P, ISSEKUTZ Jr B . Role of extramuscular energy sources in the metabolism of the exercising dog. J Appl Physiol. 1967; 22(4):615-22. DOI: 10.1152/jappl.1967.22.4.615. View

Kornberg A, PRICER Jr W . Enzymatic synthesis of the coenzyme A derivatives of long chain fatty acids. J Biol Chem. 1953; 204(1):329-43. View

Paul P, ISSEKUTZ Jr B, MILLER H . Interrelationship of free fatty acids and glucose metabolism in the dog. Am J Physiol. 1966; 211(6):1313-20. DOI: 10.1152/ajplegacy.1966.211.6.1313. View

Pette D, Klingenberg M, BUECHER T . Comparable and specific proportions in the mitochondrial enzyme activity pattern. Biochem Biophys Res Commun. 1962; 7:425-9. DOI: 10.1016/0006-291x(62)90328-5. View

HAVEL R, Carlson L, EKELUND L, Holmgren A . TURNOVER RATE AND OXIDATION OF DIFFERENT FREE FATTY ACIDS IN MAN DURING EXERCISE. J Appl Physiol. 1964; 19:613-8. DOI: 10.1152/jappl.1964.19.4.613. View

Holloszy J . Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J Biol Chem. 1967; 242(9):2278-82. View

ISSEKUTZ Jr B, MILLER H, RODAHL K . Lipid and carbohydrate metabolism during exercise. Fed Proc. 1966; 25(4):1415-20. View

10.

CLELAND K, SLATER E . Respiratory granules of heart muscle. Biochem J. 1953; 53(4):547-56. PMC: 1198191. DOI: 10.1042/bj0530547. View

11.

Randle P, Newsholme E, Garland P . Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. Biochem J. 1964; 93(3):652-65. PMC: 1214024. DOI: 10.1042/bj0930652. View

12.

Bode C, Klingenberg M . CARNITINE AND FATTY ACID OXIDATION IN MITOCHONDRIA OF VARIOUS ORGANS. Biochim Biophys Acta. 1964; 84:93-5. DOI: 10.1016/0926-6542(64)90105-2. View

13.

Holloszy J, Oscai L, Don I, Mole P . Mitochondrial citric acid cycle and related enzymes: adaptive response to exercise. Biochem Biophys Res Commun. 1970; 40(6):1368-73. DOI: 10.1016/0006-291x(70)90017-3. View

14.

Astrand P . Diet and athletic performance. Fed Proc. 1967; 26(6):1772-7. View

15.

Armstrong D, Steele R, ALTSZULER N, Dunn A, Bishop J, DE BODO R . Regulation of plasma free fatty acid turnover. Am J Physiol. 1961; 201:9-15. DOI: 10.1152/ajplegacy.1961.201.1.9. View

16.

Bremer J . Carnitine in intermediary metabolism. The metabolism of fatty acid esters of carnitine by mitochondria. J Biol Chem. 1962; 237:3628-32. View

17.

Robinson S, Edwards H, Dill D . NEW RECORDS IN HUMAN POWER. Science. 1937; 85(2208):409-10. DOI: 10.1126/science.85.2208.409. View

18.

WILLIAMS Jr J, Thorp S . Re-evaluation of cytochrome c concentrations in rat organs using a new method for cytochrome c. Biochim Biophys Acta. 1969; 189(1):25-8. DOI: 10.1016/0005-2728(69)90220-5. View

19.

PANDE S, Mead J . Long chain fatty acid activation in subcellular preparations from rat liver. J Biol Chem. 1968; 243(2):352-61. View

20.

Pattengale P, Holloszy J . Augmentation of skeletal muscle myoglobin by a program of treadmill running. Am J Physiol. 1967; 213(3):783-5. DOI: 10.1152/ajplegacy.1967.213.3.783. View