Effect of Diuretics on Mouse Blood Sugar Following Single Dose Administration

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1971 Jun 1

PMID 5091161

Citations 7

Authors

J M Foy

B L Furman

Affiliations

Soon will be listed here.

Abstract

1. Frusemide, in doses which were maximal or supramaximal in respect of its natriuretic, diuretic and kaliuretic properties, produced a dose dependent, transient hyperglycaemic response in the mouse.2. Bilateral nephrectomy resulted in a complete abolition of the hyperglycaemic response.3. The hyperglycaemic response was accompanied by a decrease in liver glycogen and was significantly attenuated by adrenalectomy, adrenal demedullation and pretreatment with dihydroergotamine (DHE).4. In the nephrectomized mouse frusemide treatment produced a marked reduction in intravenous glucose tolerance and a reduction in the plasma concentration of immunoreactive insulin following glucose administration. The drug had no detectable effect upon insulin sensitivity.5. Hydrochlorothiazide exerted no detectable effect on mouse blood sugar.6. Ethacrynic acid hyperglycaemia was obtainable after intraperitoneal or intramuscular injection, but not after intravenous injection. Intravenously administered ethacrynic acid exerted no effect upon intravenous glucose tolerance or insulin sensitivity in the nephrectomized mouse.

Citing Articles

Suppression of 18F-FDG signal in the bladder on small animal PET-CT.

Cusso L, Desco M PLoS One. 2018; 13(10):e0205610.

PMID: 30332442 PMC: 6192599. DOI: 10.1371/journal.pone.0205610.

Relation between BK-α/β4-mediated potassium secretion and ENaC-mediated sodium reabsorption.

Wen D, Cornelius R, Rivero-Hernandez D, Yuan Y, Li H, Weinstein A Kidney Int. 2014; 86(1):139-45.

PMID: 24573316 PMC: 4077913. DOI: 10.1038/ki.2014.14.

Effect of single dose administration of diuretics on the blood sugar of alloxan-diabetic mice or mice made hyperglycaemic by the acute administration of diazoxide.

Foy J, Furman B Br J Pharmacol. 1973; 47(1):124-32.

PMID: 4717012 PMC: 1776513. DOI: 10.1111/j.1476-5381.1973.tb08165.x.

The hypoglycaemic effect of 5-hydroxytryptophan.

Furman B Br J Pharmacol. 1974; 50(4):575-80.

PMID: 4548658 PMC: 1776716. DOI: 10.1111/j.1476-5381.1974.tb08591.x.

Diuretics and carbohydrate metabolism: the effects of furosemide and amiloride on blood glucose, plasma insulin and cations in the rat.

Aynsley-Green A, Alberti K Diabetologia. 1973; 9(1):34-42.

PMID: 4267106 DOI: 10.1007/BF01225998.

References

Haslewood G, Strookman T . A method for the estimation of "true" sugar in 0.05 ml. of blood. Biochem J. 1939; 33(6):920-3. PMC: 1264466. DOI: 10.1042/bj0330920. View

Kennedy B, Ellis S . Interactions of catecholamines and adrenergic blocking agents at receptor sites mediating glycogenolysis in the rat. Arch Int Pharmacodyn Ther. 1969; 177(2):390-406. View

Breckenridge A, Welborn T, Dollery C, Fraser R . Glucose tolerance in hypertensive patients on long-term diuretic therapy. Lancet. 1967; 1(7481):61-4. DOI: 10.1016/s0140-6736(67)92470-1. View

FORMANEK K, KENNER T . Special features of the action of a new diuretic. Br J Pharmacol Chemother. 1966; 26(1):27-33. PMC: 1510782. DOI: 10.1111/j.1476-5381.1966.tb01807.x. View

Wales J, Grant A, WOLFF F . Studies on the hyperglycemic effects of nonthiazide diuretics. J Pharmacol Exp Ther. 1968; 159(1):229-35. View

Lebacq E, Marcq M . A study of the mechanism of ethacrynic acid induced hyperglycemia. Rev Fr Etud Clin Biol. 1967; 12(2):160-2. View

Feldman E, Diamond S . Ethacrynic acid: a non-diabetogenic diuretic. Dis Chest. 1967; 51(3):282-7. DOI: 10.1378/chest.51.3.282. View

Jackson W, Nellen M . Effect of frusemide on carbohydrate metabolism, blood-pressure, and other modalities. A comparison with chlorothiazide. Br Med J. 1966; 2(5509):333-6. PMC: 1943166. DOI: 10.1136/bmj.2.5509.333. View

Toivonen S, Mustala O . Diabetogenic action of frusemide. Br Med J. 2010; 1(5492):920-1. PMC: 1844386. DOI: 10.1136/bmj.1.5492.920-c. View

10.

GOLDNER M, ZAROWITZ H, Akgun S . Hyperglycemia and glycosuria due to thiazide derivatives administered in diabetes mellitus. N Engl J Med. 1960; 262:403-5. DOI: 10.1056/NEJM196002252620807. View

11.

Schaefer H . [MODERN DIURETICS AND THEIR SIDE-EFECTS IN DIABETES MELLITUS]. Med Welt. 1964; 16:922-6. View

12.

Andersen O, Persson I . Carbohydrate metabolism during treatment with chlorthalidone and ethacrynic acid. Br Med J. 1968; 2(5608):798-801. PMC: 1991605. DOI: 10.1136/bmj.2.5608.798. View

13.

Hales C, Randle P . Immunoassay of insulin with insulin-antibody precipitate. Biochem J. 1963; 88:137-46. PMC: 1203862. DOI: 10.1042/bj0880137. View

14.

Foy J . Acute diuretic induced hyperglycaemia in rats. Life Sci. 1967; 6(9):897-902. DOI: 10.1016/0024-3205(67)90074-4. View

15.

LOUBATIERES A, Mariani M, ALRIC R . The action of diazoxide on insulin secretion, medullo-adrenal secretion, and the liberation of catecholamines. Ann N Y Acad Sci. 1968; 150(2):226-41. DOI: 10.1111/j.1749-6632.1968.tb19048.x. View

16.

Dige-Petersen H . [Antidiuretic affect of ethacrynic acid. Comparison with thiazide in a patient with pituitary diabetes insipidus]. Nord Med. 1966; 75(5):125-7. View

17.

Montgomery R . Determination glycogen. Arch Biochem Biophys. 1957; 67(2):378-86. DOI: 10.1016/0003-9861(57)90292-8. View

18.

Ozen M, SANDALCI O, BERKER F . Ethacrynic acid and carbohydrate metabolism. Am J Med Sci. 1966; 252(5):558-63. View

19.

Weller J, BORONDY P . EFFECTS OF BENZOTHIADIAZINE DRUGS ON CARBOHYDRATE METABOLISM. Metabolism. 1965; 14:708-14. DOI: 10.1016/0026-0495(65)90054-5. View

20.

TABACHNICK I, GULBENKIAN A, Yannell A . The hyperglycemic activity of benzothiadiazine and other diuretics. Life Sci. 1965; 4(20):1931-6. DOI: 10.1016/0024-3205(65)90048-2. View