Electrophoretic Characterization of Circulating Human Proinsulin and Insulin

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1972 Apr 1

PMID 5031265

Citations 7

Authors

R A Gutman

N R Lazarus

L RECANT

Affiliations

Soon will be listed here.

Citing Articles

Circulating proinsulin-like component in man: increased proportion in hypoinsulinemic states.

Gorden P, HENDRICKS C, Roth J Diabetologia. 1974; 10(5):469-74.

PMID: 4452432 DOI: 10.1007/BF01221640.

The interactions of proinsulin with insulin receptors on the plasma membrane of the liver.

Freychet P J Clin Invest. 1974; 54(5):1020-31.

PMID: 4421396 PMC: 301649. DOI: 10.1172/JCI107845.

Semisynthetic human [[3H2]Phe1]proinsulin.

Jones R, Rose K, Offord R Biochem J. 1987; 247(3):785-8.

PMID: 3322270 PMC: 1148480. DOI: 10.1042/bj2470785.

In vitro activity of biosynthetic human diarginylinsulin.

Zeuzem S, Stahl E, Jungmann E, Zoltobrocki M, SCHOFFLING K, Caspary W Diabetologia. 1990; 33(2):65-71.

PMID: 2184062 DOI: 10.1007/BF00401042.

Kinetics of human connecting peptide in normal and diabetic subjects.

Faber O, Hagen C, Binder C, Markussen J, Naithani V, Blix P J Clin Invest. 1978; 62(1):197-203.

PMID: 659633 PMC: 371754. DOI: 10.1172/JCI109106.

References

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Melani F, Rubenstein A, Steiner D . Human serum proinsulin. J Clin Invest. 1970; 49(3):497-507. PMC: 322497. DOI: 10.1172/JCI106259. View

Oyer P, Cho S, Peterson J, Steiner D . Studies on human proinsulin. Isolation and amino acid sequence of the human pancreatic C-peptide. J Biol Chem. 1971; 246(5):1375-86. View

Melani F, Rubenstein A, Oyer P, Steiner D . Identification of proinsulin and C-peptide in human serum by a specific immunoassay. Proc Natl Acad Sci U S A. 1970; 67(1):148-55. PMC: 283181. DOI: 10.1073/pnas.67.1.148. View

DAVOREN P . The isolation of insulin from a single cat pancreas. Biochim Biophys Acta. 1962; 63:150-3. DOI: 10.1016/0006-3002(62)90347-5. View

Steiner D, HALLUND O, Rubenstein A, Cho S, Bayliss C . Isolation and properties of proinsulin, intermediate forms, and other minor components from crystalline bovine insulin. Diabetes. 1968; 17(12):725-36. DOI: 10.2337/diab.17.12.725. View

Lazarus N, Gutman R, RECANT L . A method for electrophoretic characterization on polyacrylamide gel of circulating insulin immunoreactive substances. Anal Biochem. 1971; 40(2):241-6. DOI: 10.1016/0003-2697(71)90382-4. View

Gutman R, Lazarus N, PENHOS J, Fajans S, RECANT L . Circulating proinsulin-like material in patients with functioning insulinomas. N Engl J Med. 1971; 284(18):1003-8. DOI: 10.1056/NEJM197105062841803. View

Steiner D, Cho S, Oyer P, Terris S, Peterson J, Rubenstein A . Isolation and characterization of proinsulin C-peptide from bovine pancreas. J Biol Chem. 1971; 246(5):1365-74. View

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Schmidt D, Arens A . [Bovine proinsulin: isolation, properties and activation by trypsin]. Hoppe Seylers Z Physiol Chem. 1968; 349(9):1157-68. View

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Roth J, Gorden P, Pastan I . "Big insulin": a new component of plasma insulin detected by immunoassay. Proc Natl Acad Sci U S A. 1968; 61(1):138-45. PMC: 285915. DOI: 10.1073/pnas.61.1.138. View