"Big Insulin": a New Component of Plasma Insulin Detected by Immunoassay

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1968 Sep 1

PMID 4301586

Citations 35

Authors

J Roth

P Gorden

I Pastan

Affiliations

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References

Berson S, Yalow R . Species-specificity of human antibeef, pork insulin serum. J Clin Invest. 1959; 38:2017-25. PMC: 441789. DOI: 10.1172/JCI103980. View

Yalow R, Berson S . Immunoassay of endogenous plasma insulin in man. J Clin Invest. 1960; 39:1157-75. PMC: 441860. DOI: 10.1172/JCI104130. View

SKOM J, TALMAGE D . Nonprecipitating insulin antibodies. J Clin Invest. 1958; 37(6):783-6. PMC: 1062733. DOI: 10.1172/JCI103664. View

MOLONEY P, Coval M . Antigenicity of insulin: diabetes induced by specific antibodies. Biochem J. 1955; 59(2):179-85. PMC: 1216116. DOI: 10.1042/bj0590179. View

Berson S, Yalow R . Some current controversies in diabetes research. Diabetes. 1965; 14(9):549-72. DOI: 10.2337/diab.14.9.549. View

Yalow R, Berson S . Immunological specificity of human insulin: application to immunoassay of insulin. J Clin Invest. 1961; 40:2190-8. PMC: 290928. DOI: 10.1172/JCI104445. View

Steiner D, Cunningham D, SPIGELMAN L, Aten B . Insulin biosynthesis: evidence for a precursor. Science. 1967; 157(3789):697-700. DOI: 10.1126/science.157.3789.697. View

Hunter W, GREENWOOD F . Preparation of iodine-131 labelled human growth hormone of high specific activity. Nature. 1962; 194:495-6. DOI: 10.1038/194495a0. View

Berson S, Yalow R . Insulin in blood and insulin antibodies. Am J Med. 1966; 40(5):676-90. DOI: 10.1016/0002-9343(66)90148-3. View

10.

Steiner D, Oyer P . The biosynthesis of insulin and a probable precursor of insulin by a human islet cell adenoma. Proc Natl Acad Sci U S A. 1967; 57(2):473-80. PMC: 335530. DOI: 10.1073/pnas.57.2.473. View

11.

Unger R, EISENTRAUT A, Madison L . The effects of total starvation upon the levels of circulating glucagon and insulin in man. J Clin Invest. 1963; 42:1031-9. PMC: 289371. DOI: 10.1172/JCI104788. View

12.

MIRSKY I, Kawamura K . Heterogeneity of crystalline insulin. Endocrinology. 1966; 78(6):1115-9. DOI: 10.1210/endo-78-6-1115. View

13.

Yalow R, Berson S . REACTION OF FISH INSULINS WITH HUMAN INSULIN ANTISERUMS. POTENTIAL VALUE IN THE TREATMENT OF INSULIN RESISTANCE. N Engl J Med. 1964; 270:1171-8. DOI: 10.1056/NEJM196405282702207. View