The Effects of Desmethylimipramine on the Pharmacological Actions of Alpha Methyldopa in Man

Overview

Journal Eur J Clin Pharmacol

Specialty Pharmacology

Date 1979 Sep 1

PMID 499311

Citations 2

Authors

J L Reid

A J Porsius

C Zamboulis

G Polak

C A Hamilton

C R Dean

Affiliations

Soon will be listed here.

Abstract

The effect of pretreatment with the tricyclic antidepressant desmethylimipramine (DMI) 75 mg daily for 3 days on the action of oral methyldopa 750 mg was investigated in a double blind crossover design in volunteers. DMI pretreatment caused a small but not significant increase in supine systolic and diastolic blood pressure and heart rate. However, the effects of methyldopa on lying and standing blood pressure and heart rate were not markedly altered by pretreatment. In particular, the fall in standing blood pressure after methyldopa was present with and without DMI and the sedative action of methyldopa was similar. DMI alone reduced saliva production. No evidence was found that tricyclic antidepressant drugs significantly modify the hypotensive effect of methyldopa in man.

Citing Articles

Pharmacodynamic studies on mianserin and its interaction with clonidine.

Elliott H, McLean K, Sumner D, Reid J Eur J Clin Pharmacol. 1981; 21(2):97-102.

PMID: 7341285 DOI: 10.1007/BF00637508.

Assessment of the interaction between mianserin and centrally-acting antihypertensive drugs.

Elliott H, Whiting B, Reid J Br J Clin Pharmacol. 1983; 15 Suppl 2:323S-328S.

PMID: 6824563 PMC: 1427893. DOI: 10.1111/j.1365-2125.1983.tb05881.x.

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