The Interaction Between Alpha-methyl-dopa and Tricyclic Antidepressants

Overview

Journal Int J Clin Pharmacol Biopharm

Specialties Pharmacology
Pharmacy

Date 1975 Jan 1

PMID 1150364

Citations 6

Authors

H W van Spanning

P A van Zwieten

Affiliations

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Abstract

The central hypotensive action of alpha-methyl-DOPA is antagonized by tricyclic antidepressants like desipramine and imipramine. This antagonism has been demostrated in chloralose-anaesthetized cats. The drugs to be tested were infused into the left vertebral artery. The antagonism pProbably takes place in the pons-medulla region of the CNS. Probably, the alpha-adrenolytic properties of the tricyclic antidepressants bring about the blockade of central alpha-adrenergic receptors that are stimulated by alpha-methyl-noradrenaline, the biotransformation product of alpha-methyl-DOPA.

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