The Subcellular Distribution and Some Properties of the Cytochrome B Component of the Microbicidal Oxidase System of Human Neutrophils

Overview

Journal Biochem J

Specialty Biochemistry

Date 1979 Jul 15

PMID 496906

Citations 32

Authors

A W Segal

O T Jones

Affiliations

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Abstract

A novel cytochrome b has recently been described in human neutrophils. The subcellular distribution of this cytochrome was investigated by analytical fractionation on continuous sucrose gradients and it was found to have a dual localization, the major component having a similar distribution to the plasma-membrane marker [3H]concanavalin A, and a denser peak located with the specific granules. The two components were separated on discontinuous gradients and studied independently.

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