Studies on Human Leukocyte Motility. I. Effects of Alterations in PH, Electrolyte Concentration, and Phagocytosis on Leukocyte Migration, Adhesiveness, and Aggregation

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1966 Sep 1

PMID 4958802

Citations 29

Authors

R E Bryant

R M DESPREZ

M H VanWay

D E ROGERS

Affiliations

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Abstract

Leukocyte migration was studied in a microhematocrit system which permitted evaluation of the separate effects of leukocyte adhesiveness, intrinsic cell motility, and leukocyte clumping. Leukocyte adhesion to glass required the presence of magnesium ion, was totally independent of calcium ion, and was partially dependent on heat-labile plasma factors. Leukocyte migration was unimpaired by marked acidosis or by wide variations in sodium, potassium, or calcium concentrations. Marked impairment of individual leukocyte motility and increased leukocyte aggregation were observed after phagocytosis of particulate matter, suggesting a mechanism facilitating recruitment and retention of leukocytes at areas of microbial invasion.

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References

Sbarra A, Karnovsky M . The biochemical basis of phagocytosis. I. Metabolic changes during the ingestion of particles by polymorphonuclear leukocytes. J Biol Chem. 1959; 234(6):1355-62. View

Martin S, CHAUDHURI S . Effect of bacteria and their products on migration of leukocytes. Proc Soc Exp Biol Med. 1952; 81(1):286-8. DOI: 10.3181/00379727-81-19851. View

KETCHEL M, FAVOUR C . The acceleration and inhibition of migration of human leucocytes in vitro by plasma protein fractions. J Exp Med. 1955; 101(6):647-63. PMC: 2136480. DOI: 10.1084/jem.101.6.647. View

Strauss B, Stetson C . STUDIES ON THE EFFECT OF CERTAIN MACROMOLECULAR SUBSTANCES ON THE RESPIRATORY ACTIVITY OF THE LEUCOCYTES OF PERIPHERAL BLOOD. J Exp Med. 2009; 112(4):653-69. PMC: 2137241. DOI: 10.1084/jem.112.4.653. View

Hirsch J, CHURCH A . Studies of phagocytosis of group A streptococci by polymorphonuclear leucocytes in vitro. J Exp Med. 1960; 111:309-22. PMC: 2137261. DOI: 10.1084/jem.111.3.309. View