Candidiasis: Detection by Gas-liquid Chromatography of D-arabinitol, a Fungal Metabolite, in Human Serum

Overview

Journal Science

Specialty Science

Date 1979 Nov 2

PMID 493963

Citations 45

Authors

T E Kiehn

E M Bernard

J W Gold

D Armstrong

Affiliations

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Abstract

D-Arabinitol was identified as a major metabolite of Candida species in human subjects. Gas-liquid chromatography was used to measure the concentration of D-arabinitol in serum. The study included subjects who were healthy and cancer patients who had proven invasive candidiasis or were colonized with Candida. D-Arabinitol concentrations greater than 1.0 microgram per milliliter were found in serum from patients with invasive infection. This technique may prove valuable in the diagnosis of invasive candidiasis.

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