A Novel Molecular Imprinting Polymer for the Selective Adsorption of D-arabinitol from Spiked Urine

Overview

Journal Turk J Chem

Publisher Scientific and Technological Research Council of Turkey

Date 2021 Jan 25

PMID 33488227

Citations 1

Authors

Yuni Retnaningtyas

Ganden Supriyanto

Ni Nyoman Tri Puspaningsih

Roedi Irawan

Siswandono Siswodihardjo

Affiliations

Soon will be listed here.

Abstract

In this research, molecular imprinting polymers (MIPs) for D-arabinitol were synthesized using a bulk polymerization method through a noncovalent approach. The MIPs were prepared by using D-arabinitol as a template, acrylamide as a functional monomer, ethylene glycol dimethacrylateas cross-linker, benzoyl peroxide as an initiator and dimethyl sulfoxideas a porogen. MIPS was synthesized in several formulas with a different molar ratio of template to functional monomers and cross-linker. Fourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) were used to characterize the MIPs produced. A batch rebinding assay was used to test the binding efficiency of each formula. Batch rebinding test results revealed that MIPsF3 with a molar ratio of the template: monomer and crosslinker ratio respectively (1: 4: 25) had the highest binding capacity at 1.56 mgg . The results of isotherm adsorption showed that the MIPs produced followed the Freundlich equation with an R-value of 0.97. The MIPs produced was also selective toward its isomeric compounds (i.e. L-arabinitol, adonitol, xylitol, and glucose). The extraction efficiency of the MIPs against D-arabinitol was 88.98%.

Citing Articles

Silver nanoparticles (AgNPs) based selective colorimetric sensor for the detection of D-arabinitol in a urine sample.

Retnaningtyas Y, Siswodihardjo S, Satya Nugraha A Turk J Chem. 2023; 46(6):1817-1826.

PMID: 37621352 PMC: 10446936. DOI: 10.55730/1300-0527.3482.

References

Yeo S, Zhang Y, Schafer D, Campbell S, Wong B . A rapid, automated enzymatic fluorometric assay for determination of D-arabinitol in serum. J Clin Microbiol. 2000; 38(4):1439-43. PMC: 86460. DOI: 10.1128/JCM.38.4.1439-1443.2000. View

Yeo S, Huie S, Sofair A, Campbell S, Durante A, Wong B . Measurement of serum D-arabinitol/creatinine ratios for initial diagnosis and for predicting outcome in an unselected, population-based sample of patients with Candida fungemia. J Clin Microbiol. 2006; 44(11):3894-9. PMC: 1698297. DOI: 10.1128/JCM.01045-06. View

ROBOZ J, Suzuki R, HOLLAND J . Quantification of arabinitol in serum by selected ion monitoring as a diagnostic technique in invasive candidiasis. J Clin Microbiol. 1980; 12(4):594-601. PMC: 273644. DOI: 10.1128/jcm.12.4.594-601.1980. View

Gold J, Wong B, Bernard E, Kiehn T, Armstrong D . Serum arabinitol concentrations and arabinitol/creatinine ratios in invasive candidiasis. J Infect Dis. 1983; 147(3):504-13. DOI: 10.1093/infdis/147.3.504. View

Zhongbo Z, Hu J . Selective removal of estrogenic compounds by molecular imprinted polymer (MIP). Water Res. 2008; 42(15):4101-8. DOI: 10.1016/j.watres.2008.07.006. View

Stradomska T, Mielniczuk Z . Gas chromatographic determination of D-/L-arabinitol ratio in healthy Polish children. J Chromatogr B Analyt Technol Biomed Life Sci. 2002; 773(2):175-81. DOI: 10.1016/s1570-0232(02)00180-0. View

Cacho C, Turiel E, Martin-Esteban A, Perez-Conde C, Camara C . Characterisation and quality assessment of binding sites on a propazine-imprinted polymer prepared by precipitation polymerisation. J Chromatogr B Analyt Technol Biomed Life Sci. 2004; 802(2):347-53. DOI: 10.1016/j.jchromb.2003.12.018. View

Larsson L, Pehrson C, Wiebe T, Christensson B . Gas chromatographic determination of D-arabinitol/L-arabinitol ratios in urine: a potential method for diagnosis of disseminated candidiasis. J Clin Microbiol. 1994; 32(8):1855-9. PMC: 263891. DOI: 10.1128/jcm.32.8.1855-1859.1994. View

Reiss E, Obayashi T, Orle K, Yoshida M, Zancope-Oliveira R . Non-culture based diagnostic tests for mycotic infections. Med Mycol. 2001; 38 Suppl 1:147-59. View

10.

Shekarchi M, Pourfarzib M, Akbari-Adergani B, Mehramizi A, Javanbakht M, Dinarvand R . Selective extraction of lamivudine in human serum and urine using molecularly imprinted polymer technique. J Chromatogr B Analyt Technol Biomed Life Sci. 2013; 931:50-5. DOI: 10.1016/j.jchromb.2013.04.041. View

11.

Kiehn T, Bernard E, Gold J, Armstrong D . Candidiasis: detection by gas-liquid chromatography of D-arabinitol, a fungal metabolite, in human serum. Science. 1979; 206(4418):577-80. DOI: 10.1126/science.493963. View

12.

Lahsini R, Louhaichi M, Adhoum N, Monser L . Preparation and application of a molecularly imprinted polymer for determination of glibenclamide residues. Acta Pharm. 2013; 63(2):265-75. DOI: 10.2478/acph-2013-0017. View

13.

Tang W, Du W, Guo P, Wu N, Du K, Xu C . Molecularly Imprinted Solid Phase Extraction using Bismethacryloyl-β-cyclodextrin and Methacrylic Acid as Double Functional Monomers for Selective Analysis of Glycyrrhizic Acid in Aqueous Media. J Chromatogr Sci. 2017; 55(2):166-173. PMC: 7109652. DOI: 10.1093/chromsci/bmw161. View

14.

Montagna M, Caggiano G, Borghi E, Morace G . The role of the laboratory in the diagnosis of invasive candidiasis. Drugs. 2009; 69 Suppl 1:59-63. DOI: 10.2165/11315630-000000000-00000. View

15.

Christensson B, Wiebe T, Pehrson C, Larsson L . Diagnosis of invasive candidiasis in neutropenic children with cancer by determination of D-arabinitol/L-arabinitol ratios in urine. J Clin Microbiol. 1997; 35(3):636-40. PMC: 229641. DOI: 10.1128/jcm.35.3.636-640.1997. View

16.

Sadeghi S, Jahani M . Selective solid-phase extraction using molecular imprinted polymer sorbent for the analysis of florfenicol in food samples. Food Chem. 2013; 141(2):1242-51. DOI: 10.1016/j.foodchem.2013.04.027. View

17.

Sigmundsdottir G, Christensson B, Bjorklund L, Hakansson K, Pehrson C, Larsson L . Urine D-arabinitol/L-arabinitol ratio in diagnosis of invasive candidiasis in newborn infants. J Clin Microbiol. 2000; 38(8):3039-42. PMC: 87181. DOI: 10.1128/JCM.38.8.3039-3042.2000. View

18.

Christensson B, Sigmundsdottir G, Larsson L . D-arabinitol--a marker for invasive candidiasis. Med Mycol. 2000; 37(6):391-6. DOI: 10.1046/j.1365-280x.1999.00249.x. View

19.

Caro E, Masque N, Marce R, Borrull F, Cormack P, Sherrington D . Non-covalent and semi-covalent molecularly imprinted polymers for selective on-line solid-phase extraction of 4-nitrophenol from water samples. J Chromatogr A. 2002; 963(1-2):169-78. DOI: 10.1016/s0021-9673(02)00360-6. View

20.

Dabrowski M, Sharma P, Iskierko Z, Noworyta K, Cieplak M, Lisowski W . Early diagnosis of fungal infections using piezomicrogravimetric and electric chemosensors based on polymers molecularly imprinted with d-arabitol. Biosens Bioelectron. 2016; 79:627-35. DOI: 10.1016/j.bios.2015.12.088. View