Histocompatibility Studies in a Closely Bred Colony of Dogs. I. Influence of Leukocyte Group Antigens Upon Renal Allograft Survival in the Unmodified Host

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1970 May 1

PMID 4910142

Citations 11

Authors

F T RAPAPORT

T Hanaoka

T Shimada

F D CANNON

J W FERREBEE

Affiliations

Soon will be listed here.

Abstract

The establishment of a closely bred colony of beagles with known leukocyte group phenotypes has permitted an assessment of the role of leukocyte group antigens in conditioning the survival of renal allografts in the unmodified host. 22 kidney transplants obtained from leukocyte group-compatible donors were accorded a mean survival time of 25.5 days, as compared with 13.1 days for 27 transplants obtained from incompatible donors. Donor-recipient coefficients of correlation and Swisher erythrocyte group incompatibilities did not appear to affect the observed results. The mean survival time of 21 renal allografts performed in randomly selected mongrel dogs was 9.5 days. Availability of a carefully characterized and phenotyped canine population may be useful in further studies of the comparative immunogenicity of the major transplantable organs, and of methods designed to facilitate prolonged organ transplant survival in the mammalian host.

Citing Articles

Induction of Tolerance Towards Solid Organ Allografts Using Hematopoietic Cell Transplantation in Large Animal Models.

Graves S, Mathes D, Storb R OBM Transplant. 2020; 3(3).

PMID: 32944710 PMC: 7494220. DOI: 10.21926/obm.transplant.1903080.

Histocompatibility studies in a closely bred colony of dogs. II. Influence of the DL-A system of canine histocompatibility upon the survival of cardiac allografts.

Rapaport R, Boyd A, SPENCER F, LOWER R, Dausset J, CANNON F J Exp Med. 1971; 133(2):260-74.

PMID: 4943931 PMC: 2138901. DOI: 10.1084/jem.133.2.260.

Histocompatibility studies in a closely bred colony of dogs. 3. Genetic definition of the DL-A system of canine histocompatibility, with particular reference to the comparative immunogenicity of the major transplantable organs.

Dausset J, RAPAPORT F, CANNON F, FERREBEE J J Exp Med. 1971; 134(5):1222-37.

PMID: 4939370 PMC: 2139009. DOI: 10.1084/jem.134.5.1222.

Interaction of histocompatibility (HL-A) antibodies and complement with synchronized human lymphoid cells in continuous culture.

Ferrone S, Cooper N, Pellegrino M, Reisfeld R J Exp Med. 1973; 137(1):55-68.

PMID: 4734592 PMC: 2139359. DOI: 10.1084/jem.137.1.55.

The influence of DL-A compatibility on the survival of hepatic allografts in unmodified mongrel dogs.

Ranson J, RAPAPORT F, FERREBEE J, CANNON F, Adams P, LOCALIO S Ann Surg. 1974; 179(6):846-52.

PMID: 4599072 PMC: 1355913. DOI: 10.1097/00000658-197406000-00005.

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