Lymphocyte Function in Myasthenia Gravis

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 1979 Aug 1

PMID 490180

Citations 3

Authors

S Kawanami

A Kanaide

Y Itoyama

Y Kuroiwa

Affiliations

Soon will be listed here.

Abstract

Mitogen-induced blastoid transformation of peripheral blood lymphocytes from patients with myasthenia gravis was studied using a microplate culture technique and evaluated with 3H-thymidine incorporation. It was found that both phytohaemagglutinin and pokeweed mitogen responses decreased significantly in patients with myasthenia gravis. In myasthenic crisis, indices of stimulation by phytohaemagglutination became very low. The autologous plasma neither inhibited nor facilitated mitogenic responses of lymphocytes. The decreased mitogen responsiveness of lymphocytes suggests that part of the T lymphocyte function is subnormal in myasthenia.

Citing Articles

Clinical and immunological associations in myasthenia gravis. 2. Cell-mediated immunity.

Sagar H, DAVIES-JONES G, Allonby I J Neurol Neurosurg Psychiatry. 1980; 43(11):971-7.

PMID: 6969295 PMC: 490747. DOI: 10.1136/jnnp.43.11.971.

Immune disease and HLA associations with myasthenia gravis.

Behan P J Neurol Neurosurg Psychiatry. 1980; 43(7):611-21.

PMID: 6967515 PMC: 490628. DOI: 10.1136/jnnp.43.7.611.

Phenotypic and functional analysis of lymphocytes in myasthenia gravis.

Levinson A, Lisak R, Zweiman B, Kornstein M Springer Semin Immunopathol. 1985; 8(3):209-33.

PMID: 3901367 DOI: 10.1007/BF00197297.

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