Immunopathology of Lymphocytic Choriomeningitis Viurs Infection of Newborn Mice. Antithymocyte Serum Effects on Glomerulonephritis and Wasting Disease

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1968 Apr 1

PMID 4868581

Citations 26

Authors

M S Hirsch

F A Murphy

M D Hicklin

Affiliations

Soon will be listed here.

Abstract

Antithymocyte serum, when administered neonatally to mice, delayed the maturation of the lymphoid system, permitting development of cellular tolerance to LCM virus at an older age than is ordinarily possible. Humoral antibody formation was not prevented and the animals exhibited the paradox of high titers of both circulating virus and antibody. This, in turn, was followed by a chronic immunopathologic glomerulonephritis in most animals. Some animals developed wasting disease between 1 and 2 months of age, characterized by reticular cell hyperplasia and widespread infiltration into tissues and organs.

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