Efficacy of Antimicrobial Therapy in Experimental Rat Pneumonia: Effects of Impaired Phagocytosis

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1979 Jul 1

PMID 478640

Citations 18

Authors

M F Michel

Affiliations

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Abstract

The importance of intact host defense mechanisms for successful antimicrobial therapy was investigated in an animal model. Recovery from lobar pneumococcal pneumonia as a result of penicillin therapy was studied in normal rats and in rats treated with cobra venom factor. This factor was used to selectively suppress the phagocytosis of pneumococci as a result of complement depletion. Although complete recovery from the infection occurred in normal rats after appropriate penicillin therapy, this was not the case in cobra venom factor-treated rats. Within the limitations of this study, evidence is presented for loss of antibiotic activity as a consequence of impaired phagocytosis.

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