Natural Immunity to Bacterial Infections: the Relation of Complement to Heat-labile Opsonins

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1969 Aug 1

PMID 4390986

Citations 9

Authors

M R Smith

H S Shin

W B WOOD Jr

Affiliations

Soon will be listed here.

Abstract

Heat-labile opsonins to pneumococci in normal mammalian sera, unlike antibodies, fail to interact with the bacteria at 0 degrees C and require Ca(++) and/or Mg(++). They are readily removed from serum by antigen-antibody complexes that fix complement (C) and are inhibited by reagents that inactivate various C components. The principal heat-labile opsonin to pneumococci is activated C3 (C3(b)), but a slight enhancing effect is exerted by one or more of the late-reacting components of the hemolytic complement system (C5-C9). Since heat-labile opsonins are immunologically polyspecific, they presumably play a broad protective role in the early (preantibody) phase of acute bacterial infections.

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