Increased Liver L-serine-pyruvate Aminotransferase Activity Under Gluconeogenic Conditions

Overview

Journal Biochem J

Specialty Biochemistry

Date 1973 May 1

PMID 4723229

Citations 16

Authors

E V ROWSELL

J A CARNIE

Affiliations

Soon will be listed here.

Abstract

Rat liver l-serine-pyruvate aminotransferase activity exceeds markedly the normal adult value (a) in the neonatal period, (b) after glucagon injection and (c) after alloxan injection, observations that reinforce the suggestion from comparative findings that the aminotransferase has a role in gluconeogenesis. Some findings, however, argue in favour of l-serine dehydratase as the enzyme of gluconeogenesis from l-serine.

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References

Yeung D, Oliver I . Gluconeogenesis from amino acids in neonatal rat liver. Biochem J. 1967; 103(3):744-8. PMC: 1270478. DOI: 10.1042/bj1030744. View

Hancock I, BADDILEY J . Biosynthesis of the wall teichoic acid in Bacillus licheniformis. Biochem J. 1972; 127(1):27-37. PMC: 1178556. DOI: 10.1042/bj1270027. View

Johnson B, Walsh D, SALLACH H . CHANGES IN THE ACTIVITIES OF D-GLYCERATE AND D-3-PHOSPHOGLYCERATE DEHYDROGENASES IN THE DEVELOPING RAT LIVER. Biochim Biophys Acta. 1964; 85:202-5. DOI: 10.1016/0926-6569(64)90241-x. View

DICKENS F, Williamson D . Metabolism of D- and L-[3-14C]glycerate by liver tissue of the rat. Biochem J. 1960; 77:356-63. PMC: 1204992. DOI: 10.1042/bj0770356. View

Ballard F, Oliver I . CARBOHYDRATE METABOLISM IN LIVER FROM FOETAL AND NEONATAL SHEEP. Biochem J. 1965; 95:191-200. PMC: 1215193. DOI: 10.1042/bj0950191. View

Evered D, Roffe L . Liver serine dehydratase levels in the developing rat. Comp Biochem Physiol B. 1971; 39(2):377-81. DOI: 10.1016/0305-0491(71)90182-9. View

Greengard O, Dewey H . Initiation by glucagon of the premature development of tyrosine aminotransferase, serine dehydratase, and glucose-6-phosphatase in fetal rat liver. J Biol Chem. 1967; 242(12):2986-91. View

Nakagawa H, Nagai K . Cold adaptation. I. Effect of cold-exposure on gluconeogenesis. J Biochem. 1971; 69(5):923-34. DOI: 10.1093/oxfordjournals.jbchem.a129543. View

GOSWAMI M, Boulekbache H, Meury F . Age-correlated variations of rat liver serine dehydratase and tyrosine aminotransferase activities--a comparative analysis. Comp Biochem Physiol B. 1972; 41(2):323-30. DOI: 10.1016/0305-0491(72)90034-x. View

10.

DICKENS F, Williamson D . Studies on the metabolism of hydroxypyruvate in animal tissues. Biochem J. 1959; 72:496-508. PMC: 1196962. DOI: 10.1042/bj0720496. View

11.

Holzer H, HOLLDORF A . [Isolation of D-glycerate dehydrogenase, some properties of the enzyme and its application to the enzymic-optic determination of hydroxypyruvate in presence of pyruvate]. Biochem Z. 1957; 329(4):292-312. View

12.

ROWSELL E, Snell K, CARNIE J . Liver-L-alanine-glyoxylate and L-serine-pyruvate aminotransferase activities: an apparent association with gluconeogenesis. Biochem J. 1969; 115(5):1071-3. PMC: 1185249. DOI: 10.1042/bj1151071. View

13.

Vernon R, Walker D . Changes in activity of some enzymes involved in glucose utilization and formation in developing rat liver. Biochem J. 1968; 106(2):321-9. PMC: 1198506. DOI: 10.1042/bj1060321. View

14.

Yeung D, Oliver I . The postnatal induction of serine dehydratase in rat liver. Comp Biochem Physiol A Comp Physiol. 1971; 40(1):135-44. DOI: 10.1016/0300-9629(71)90156-3. View

15.

Yeung D, Oliver I . Development of gluconeogenesis in neonatal rat liver. Effect of premature delivery. Biochem J. 1967; 105(3):1229-33. PMC: 1198445. DOI: 10.1042/bj1051229. View

16.

Ishikawa E, NINAGAWA T, Suda M . HORMONAL AND DIETARY CONTROL OF SERINE DEHYDRATASE IN RAT LIVER. J Biochem. 1965; 57:506-13. DOI: 10.1093/oxfordjournals.jbchem.a128109. View

17.

Vernon R, Eaton S, Walker D . Carbohydrate formation from various precursors in noenatal rat liver. Biochem J. 1968; 110(4):725-31. PMC: 1187446. DOI: 10.1042/bj1100725. View

18.

Jost J, Khairallah E, Pitot H . Studies on the induction and repression of enzymes in rat liver. V. Regulation of the rate of synthesis and degradation of serine dehydratase by dietary amino acids and glucose. J Biol Chem. 1968; 243(11):3057-66. View

19.

SALLACH H, Sanborn T, Bruin W . Dietary and hormonal regulation of hepatic biosynthetic and catabolic enzymes of serine metabolism in rats. Endocrinology. 1972; 91(4):1054-63. DOI: 10.1210/endo-91-4-1054. View