No Increased Chromosome Breakage in Three Bloom's Syndrome Heterozygotes

Overview

Journal J Med Genet

Specialty Genetics

Date 1979 Jun 1

PMID 469900

Citations 4

Authors

E M Kuhn

E THERMAN

Affiliations

Soon will be listed here.

Abstract

The frequency of chromosome aberrations in the lymphocytes of three established heterozygotes for the Bloom's syndrome gene (ages 67, 57, 46) was compared to that in controls (ages 68, 67, 61, 46, 34). The main part of the study was done on coded slides. No difference was found between the heterozygotes and the control group, except for one control (aged 46) who had a significantly higher number of chromosome aberrations than the others.

Citing Articles

Mitotic crossing-over and segregation in man.

THERMAN E, Kuhn E Hum Genet. 1981; 59(2):93-100.

PMID: 7035337 DOI: 10.1007/BF00293053.

Evidence for chromosome instability in vivo in Bloom syndrome: increased numbers of micronuclei in exfoliated cells.

Rosin M, German J Hum Genet. 1985; 71(3):187-91.

PMID: 4065890 DOI: 10.1007/BF00284570.

In vivo chromosomal instability in ataxia-telangiectasia homozygotes and heterozygotes.

Rosin M, Ochs H Hum Genet. 1986; 74(4):335-40.

PMID: 3793095 DOI: 10.1007/BF00280482.

Evidence for increased in vivo mutation and somatic recombination in Bloom's syndrome.

Langlois R, Bigbee W, Jensen R, German J Proc Natl Acad Sci U S A. 1989; 86(2):670-4.

PMID: 2911598 PMC: 286535. DOI: 10.1073/pnas.86.2.670.

References

German J, Archibald R, Bloom D . CHROMOSOMAL BREAKAGE IN A RARE AND PROBABLY GENETICALLY DETERMINED SYNDROME OF MAN. Science. 1965; 148(3669):506-7. DOI: 10.1126/science.148.3669.506. View

Kuhn E . Mitotic chiasmata and other quadriradials in mitomycin C-treated Bloom's syndrome lymphocytes. Chromosoma. 1978; 66(3):287-97. DOI: 10.1007/BF00330557. View

HUSTINX T, Ter Haar B, Scheres J, RUTTEN F, Weemaes C, Hoppe R . Bloom's syndrome in two Dutch families. Clin Genet. 1977; 12(2):85-96. DOI: 10.1111/j.1399-0004.1977.tb00907.x. View

THERMAN E, Kuhn E . Cytological demonstration of mitotic crossing-over in man. Cytogenet Cell Genet. 1976; 17(5):254-67. DOI: 10.1159/000130721. View

Chaganti R, Schonberg S, German J . A manyfold increase in sister chromatid exchanges in Bloom's syndrome lymphocytes. Proc Natl Acad Sci U S A. 1974; 71(11):4508-12. PMC: 433916. DOI: 10.1073/pnas.71.11.4508. View

Bartram C, Passarge E . Chromatid exchanges in ataxia telangiectasia, Bloom syndrome, Werner syndrome, and xeroderma pigmentosum. Ann Hum Genet. 1976; 40(1):79-86. DOI: 10.1111/j.1469-1809.1976.tb00166.x. View

German J . Genes which increase chromosomal instability in somatic cells and predispose to cancer. Prog Med Genet. 1972; 8:61-101. View

Littlefield L, GOH K . Cytogenetic studies in control men and women. I. Variations in aberration frequencies in 29,709 metaphases from 305 cultures obtained over a three-year period. Cytogenet Cell Genet. 1973; 12(1):17-34. DOI: 10.1159/000130434. View

Swift M . Fanconi's anaemia in the genetics of neoplasia. Nature. 1971; 230(5293):370-3. DOI: 10.1038/230370a0. View

10.

Kuhn E . Localization by Q-banding of mitotic chiasmata in cases of Bloom's syndrome. Chromosoma. 1976; 57(1):1-11. DOI: 10.1007/BF00292945. View

11.

AULA P, von Koskull H . Distribution of spontaneous chromosome breaks in human chromosomes. Hum Genet. 1976; 32(2):143-8. DOI: 10.1007/BF00291497. View

12.

Doyle C . The cytogenetics of 90 patients with idiopathic mental retardation/malformation syndromes and of 90 normal subjects. Hum Genet. 1976; 33(2):131-46. DOI: 10.1007/BF00281887. View

13.

Ayme S, Mattei J, Mattei M, Aurran Y, Giraud F . Nonrandom distribution of chromosome breaks in cultured lymphocytes of normal subjects. Hum Genet. 1976; 31(2):161-75. DOI: 10.1007/BF00296144. View

14.

Sperling K, Goll U, Kunze J, Ludtke E, Tolksdorf M, Obe G . Cytogenetic investigations in a new case of Bloom's syndrome. Hum Genet. 1976; 31(1):47-52. DOI: 10.1007/BF00270398. View

15.

Swift M, Sholman L, Perry M, Chase C . Malignant neoplasms in the families of patients with ataxia-telangiectasia. Cancer Res. 1976; 36(1):209-15. View

16.

Mattevi M, Salzano F . Senescence and human chromosome changes. Humangenetik. 1975; 27(1):1-8. DOI: 10.1007/BF00283497. View

17.

Lubs H, Samuelson J . Chromosome abnormalities in lymphocytes from normal human subjects. A study of 3,720 cells. Cytogenetics. 1967; 6(6):402-11. DOI: 10.1159/000129958. View