Distribution of Spontaneous Chromosome Breaks in Human Chromosomes

Overview

Journal Hum Genet

Specialty Genetics

Date 1976 May 19

PMID 1270073

Citations 15

Authors

P AULA

H von Koskull

Affiliations

Soon will be listed here.

Abstract

Localization of chromosome breaks in human chromosomes was analyzed in 264 peripheral lymphocyte cultures. Three hundred and sixty-nine chromosome breaks could be exactly localized to a chromosome band or region of the Paris Conference nomenclature. The distribution of breaks in the chromosome regions was found to be nonrandom. Chromosome 3 alone had 23% of the breaks and region 3p2 had 13% of the total breaks. Some other chromosome regions, such as 5p1, 9q1, 14q2, and 16q2 also displayed clustering of breaks. Sex chromosomes had less breaks than expected. Spontaneous chromosome breaks were almost exclusively located in the lightly stained G bands.

Citing Articles

Hotspots of mutation and breakage in dog and human chromosomes.

Webber C, Ponting C Genome Res. 2005; 15(12):1787-97.

PMID: 16339377 PMC: 1356117. DOI: 10.1101/gr.3896805.

Multicolor FISH analysis of chromosomal breaks, duplications, deletions, and numerical abnormalities in the sperm of healthy men.

Sloter E, Lowe X, Moore II D, Nath J, Wyrobek A Am J Hum Genet. 2000; 67(4):862-72.

PMID: 10961911 PMC: 1287891. DOI: 10.1086/303088.

An analysis of human sperm chromosome breakpoints.

Estop A, Marquez C, Munne S, Navarro J, Cieply K, Van Kirk V Am J Hum Genet. 1995; 56(2):452-60.

PMID: 7847382 PMC: 1801134.

Translocations of chromosome 12. II. A comparison of the distribution of sites of spontaneous and induced breakages.

Ford J Hum Genet. 1981; 58(3):279-81.

PMID: 7327548 DOI: 10.1007/BF00294923.

Unstable familial translocations: A t(11;22)mat inherited as a t(11;15).

Tomkins D Am J Hum Genet. 1981; 33(5):745-51.

PMID: 7294023 PMC: 1685141.

References

von Koskull H, AULA P . Nonrandom distribution of chromosome breaks in Fanconi's anemia. Cytogenet Cell Genet. 1973; 12(6):423-34. DOI: 10.1159/000130485. View

Leisti J . Structural variation in human nitotic chromosomes. Ann Acad Sci Fenn Biol. 1971; 179:1-69. View

CASPERSSON T, Haglund U, Lindell B, ZECH L . Radiation-induced non-random chromosome breakage. Exp Cell Res. 1972; 75(2):541-3. DOI: 10.1016/0014-4827(72)90469-7. View

Holmberg M, Jonasson J . Preferential location of x-ray induced chromosome breakage in the R-bands of human chromosomes. Hereditas. 1973; 74(1):57-67. DOI: 10.1111/j.1601-5223.1973.tb01104.x. View

Sumner A, Evans H, Buckland R . New technique for distinguishing between human chromosomes. Nat New Biol. 1971; 232(27):31-2. DOI: 10.1038/newbio232031a0. View

Patil S, Ruddle F, Lubs H . The lymphocyte as a dosimeter: comparison of somatic chromosome aberrations in 522 newborn infants and 602 mothers. Humangenetik. 1972; 14(4):306-13. DOI: 10.1007/BF00290172. View

BROGGER A . Apparently spontaneous chromosome damage in human leukocytes and the nature of chromatid gaps. Humangenetik. 1971; 13(1):1-14. DOI: 10.1007/BF00446408. View

SEABRIGHT M . High resolution studies on the pattern of induced exchanges in the human karyotype. Chromosoma. 1973; 40(4):333-46. DOI: 10.1007/BF00399426. View

Cooke P, SEABRIGHT M, Wheeler M . The differential distribution of X-ray induced chromosome lesions in trypsin-banded preparations from human subjects. Humangenetik. 1975; 28(3):221-31. DOI: 10.1007/BF00278548. View

10.

Goodman R, FECHHEIMER N, Miller F, Miller R, Zartman D . Chromosomal alterations in three age groups of human females. Am J Med Sci. 1969; 258(1):26-34. DOI: 10.1097/00000441-196907000-00004. View

11.

Jacobs P, BUCKTON K, Cunningham C, Newton M . An analysis of the break points of structural rearrangements in man. J Med Genet. 1974; 11(1):50-64. PMC: 1013088. DOI: 10.1136/jmg.11.1.50. View

12.

Obe G, LUERS H . Inter- and intrachromosomal distribution of achromatic lesions and chromatid breaks in human chromosomes. Mutat Res. 1972; 16(3):337-9. DOI: 10.1016/0027-5107(72)90167-4. View

13.

Lubs H, Samuelson J . Chromosome abnormalities in lymphocytes from normal human subjects. A study of 3,720 cells. Cytogenetics. 1967; 6(6):402-11. DOI: 10.1159/000129958. View

14.

SCHROEDER T, ANSCHUTZ F, Knopp A . [Spontaneous chromosome aberrations in familial panmyelopathy]. Humangenetik. 1964; 1(2):194-6. DOI: 10.1007/BF00389636. View

15.

Littlefield L, GOH K . Cytogenetic studies in control men and women. I. Variations in aberration frequencies in 29,709 metaphases from 305 cultures obtained over a three-year period. Cytogenet Cell Genet. 1973; 12(1):17-34. DOI: 10.1159/000130434. View

16.

Morad M, Jonasson J, LINDSTEN J . Distribution of mitomycin C induced breaks on human chromosomes. Hereditas. 1973; 74(2):273-81. DOI: 10.1111/j.1601-5223.1973.tb01128.x. View