Reversibility of Protein Binding of Penicillins: an in Vitro Study Employing a Rapid Diafiltration Process

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 1972 May 1

PMID 4670485

Citations 6

Authors

M Barza

H Vine

L WEINSTEIN

Affiliations

Soon will be listed here.

Abstract

The reversibility of human serum protein binding of oxacillin, nafcillin, and cephalothin was investigated by using a diafiltration technique. While the temperature, pH, and protein concentration were kept constant, 20% of the serum volume was exchanged every 4 to 5 min. The binding of all three drugs was rapidly reversible, and the percentage of protein binding remained the same throughout the experiment.

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