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Production of Kinins in Bovine Anaphylactic Shock

Overview
Journal Br J Pharmacol
Publisher Wiley
Specialty Pharmacology
Date 1972 Feb 1
PMID 4668595
Citations 13
Authors
P Eyre
A J Lewis
Affiliations
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Abstract

Calves were sensitized by subcutaneous injection of horse serum in Freund's adjuvant. Subsequent challenge with intravenous horse serum induced increased blood kinin activity. This kinin activation correlated with the protracted fall in systemic blood pressure seen in the same animals.

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References
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Boreham P . Immune reactions and kinin formation in chronic trypanosomiasis. Br J Pharmacol Chemother. 1968; 32(3):493-504. PMC: 1570314. DOI: 10.1111/j.1476-5381.1968.tb00450.x. View
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BERALDO W . Formation of bradykinin in anaphylactic and peptone shock. Am J Physiol. 1950; 163(2):283-9. DOI: 10.1152/ajplegacy.1950.163.2.283. View