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Metabolism of Isoprenaline in Dog and Man

Overview
Journal Br J Pharmacol
Publisher Wiley
Specialty Pharmacology
Date 1972 Nov 1
PMID 4656607
Citations 26
Authors
M E Conolly
D S Davies
C T Dollery
C D Morgan
J W Paterson
M Sandler
Affiliations
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Abstract

1. The metabolism of isoprenaline has been studied in man and dog following intravenous and oral or intra-duodenal administration.2. Intravenous isoprenaline was excreted largely unchanged in urine in both species. Only one-third of the radioactivity in urine was in the form of the O-methyl metabolite.3. After oral doses in man or intraduodenal doses in dogs, plasma radioactivity was almost entirely as conjugated isoprenaline and this metabolite accounted for more than 80% of radioactivity in urine.4. Catechol-O-methyl transferase may be less important than Uptake(2) in limiting the pharmacological action of isoprenaline.5. Pharmacological response (heart-rate increase) was related to plasma concentration of isoprenaline only after rapid intravenous injections. In dogs, following prolonged infusion or intraduodenal doses, heart rate returned to base-line values when plasma concentrations of isoprenaline were high.

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References
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