The Effects of Dipyridamole on the Myocardial Vasodilator Actions of Noradrenaline, Isoprenaline and Adenosine

Overview

Journal Br J Pharmacol

Publisher Wiley

Specialty Pharmacology

Date 1972 Dec 1

PMID 4655263

Citations 5

Authors

J R Parratt

R M Wadsworth

Affiliations

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Abstract

1. In anaesthetized cats, intravenous adenosine infusions decreased resistance to blood flow in the myocardial vascular bed. This effect of adenosine was augmented during the 60 min following the intravenous injection of dipyridamole (1 mg/kg).2. In different experiments, intravenous infusions of noradrenaline caused either a slight increase or a slight decrease in myocardial vascular resistance. The dilator component of the action of noradrenaline was not augmented by dipyridamole.3. Isoprenaline infusions decreased the resistance of the myocardial bed. This effect was unaltered after dipyridamole.4. These results do not support the hypothesis that part of the effect of catecholamines on myocardial vascular resistance involves the release of adenosine from hypoxic myocardial cells.

Citing Articles

The effects of dipyridamole on the guinea-pig ileal longitudinal muscle-myenteric plexus preparation.

DOWDLE E, Maske R Br J Pharmacol. 1980; 71(1):235-44.

PMID: 7470739 PMC: 2044429. DOI: 10.1111/j.1476-5381.1980.tb10931.x.

The effects of dipyridamole on coronary post-occlusion hyperaemia and on myocardial vasodilatation induced by systemic hypoxia.

Parratt J, Wadsworth R Br J Pharmacol. 1972; 46(4):594-601.

PMID: 4655264 PMC: 1666379. DOI: 10.1111/j.1476-5381.1972.tb06886.x.

The coronary endothelium: a highly active metabolic barrier for adenosine.

Nees S, Herzog V, Becker B, Bock M, Des Rosiers C, Gerlach E Basic Res Cardiol. 1985; 80(5):515-29.

PMID: 3000345 DOI: 10.1007/BF01907915.

Adenosine and dipyridamole actions and interactions on isolated coronary artery strips of cattle.

Kalsner S Br J Pharmacol. 1975; 55(3):439-45.

PMID: 1203630 PMC: 1666698. DOI: 10.1111/j.1476-5381.1975.tb06949.x.

The release of a coronary vasodilator metabolite from the guinea-pig isolated perfused heart stimulated by catecholamines, histamine and electrical pacing and by exposure to anoxia.

Broadley K Br J Pharmacol. 1976; 58(1):89-100.

PMID: 974380 PMC: 1667132. DOI: 10.1111/j.1476-5381.1976.tb07696.x.

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