Side-effects of Mixed Agonist-antagonist Analgesics Used in Sequential Anaesthesia
Overview
Overview
Authors
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
1 Mixed agonist-antagonist analgesics have analgesic action but also possess a range of side-effects. 2 Narcotic antagonists do not reverse the non-specific effects of opiates. 3 Under certain circumstances the effects of agonists and mixed agonist-antagonists can be additive. 4 Chronic dosage of mixed agonist-antagonists leads to a lower level of dependence than that observed with the standard narcotics. 5 Mixed agonist-antagonists may not antagonize the respiratory effects of narcotics and may result in potentiation of such depression.
References
1.
Rance M
. Animal and molecular pharmacology of mixed agonist-antagonist analgesic drugs. Br J Clin Pharmacol. 1979; 7 Suppl 3:281S-286S.
PMC: 1429313.
DOI: 10.1111/j.1365-2125.1979.tb04701.x.
View
2.
Heel R, Brogden R, Speight T, Avery G
. Butorphanol: a review of its pharmacological properties and therapeutic efficacy. Drugs. 1978; 16(6):473-505.
DOI: 10.2165/00003495-197816060-00001.
View
3.
Coltart D, Malcolm A
. Pharmacological and clinical importance of narcotic antagonists and mixed antagonists--use in cardiology. Br J Clin Pharmacol. 1979; 7 Suppl 3:309S-311S.
PMC: 1429307.
DOI: 10.1111/j.1365-2125.1979.tb04705.x.
View
4.
Orwin J, Orwin J, Price M
. A double blind comparison of buprenorphine and morphine in conscious subjects following administration by the intramuscular route. Acta Anaesthesiol Belg. 1976; 27(3):171-81.
View
5.
Nagashima H, KARAMANIAN A, Malovany R, Radnay P, Ang M, Koerner S
. Respiratory and circulatory effects of intravenous butorphanol and morphine. Clin Pharmacol Ther. 1976; 19(6):738-45.
DOI: 10.1002/cpt1976196738.
View