Animal and Molecular Pharmacology of Mixed Agonist-antagonist Analgesic Drugs

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1979 Jan 1

PMID 223616

Citations 11

Authors

M J Rance

Affiliations

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Abstract

1 The pharmacology of analgesic drugs with mixed agonist-antagonist action is reviewed in the light of the theory of drug action at single and multiple receptors. 2 Evidence for a heterogeneous population of opiate receptors in mammalian brain and in isolated tissue preparations is discussed. 3 The unusual pharmacological and pharmacokinetic profiles of the oripavine derivative buprenorphine are discussed in relation to the action of the drug at a molecular level.

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