Effect of Experimental Chronic Renal Insufficiency on Bone Mineral and Collagen Maturation

Overview

Journal J Clin Invest

Specialty General Medicine

Date 1972 Dec 1

PMID 4640950

Citations 25

Authors

J E Russell

L V Avioli

Affiliations

Soon will be listed here.

Abstract

The effect of chronic renal disease on bone matrix and mineral maturation was evaluated in rats with experimental renal insufficiency of 2-11 wk duration utilizing bromoform-toluene gradient fractionation of bone powder, pulse labeling experiments with (45)Ca and proline-(3)H differential extraction, and X-ray diffraction techniques.Maturation defects in both collagen and mineral ((45)Ca) metabolism were documented as early as 2 wk after the induction of uremia, when total bone calcium, inorganic phosphate, and hydroxyproline content were unchanged. The maturational defect progressed with advancing uremia despite insignificant changes in plasma pH and calcium, and normal bone carbonate levels. Although circulating levels of 25-hydroxycholecalciferol were significantly lower than normal in the uremic animals, pretreatment with either this vitamin D metabolite or vitamin D(3) itself failed to alter the observed changes in skeletal maturation.

Citing Articles

EFFECTS OF RENAL DYSFUNCTION ON HEALING OF COLONIC ANASTOMOSIS: EXPERIMENTAL STUDY IN WISTAR RATS.

Eduardo da Silva C, Repka J, Souza C, Matias J Arq Bras Cir Dig. 2018; 31(4):e1398.

PMID: 30539973 PMC: 6284399. DOI: 10.1590/0102-672020180001e1398.

Reductions in degree of mineralization and enzymatic collagen cross-links and increases in glycation-induced pentosidine in the femoral neck cortex in cases of femoral neck fracture.

Saito M, Fujii K, Soshi S, Tanaka T Osteoporos Int. 2006; 17(7):986-95.

PMID: 16552468 DOI: 10.1007/s00198-006-0087-0.

X-ray diffraction studies of the crystallinity of bone mineral in newly synthesized and density fractionated bone.

BONAR L, Roufosse A, Sabine W, Grynpas M, Glimcher M Calcif Tissue Int. 1983; 35(2):202-9.

PMID: 6850400 DOI: 10.1007/BF02405032.

Glucagon-stimulable adenylyl cyclase in rat liver. Effects of chronic uremia and intermittent glucagon administration.

Dighe R, Rojas F, Birnbaumer L, Garber A J Clin Invest. 1984; 73(4):1004-12.

PMID: 6323531 PMC: 425113. DOI: 10.1172/JCI111285.

Bone crystal maturation in renal osteodystrophy in humans.

BURNELL J, TEUBNER E, Wergedal J, Sherrard D J Clin Invest. 1974; 53(1):52-8.

PMID: 4808647 PMC: 301437. DOI: 10.1172/JCI107558.

References

Pellegrino E, BILTZ R . The composition of human bone in uremia. Observations on the reservoir functions of bone and demonstration of a labile fraction of bone carbonate. Medicine (Baltimore). 1965; 44(5):397-418. DOI: 10.1097/00005792-196509000-00002. View

Miller E, Martin G, MECCA C, Piez K . The biosynthesis of elastin cross-links. The effect of copper deficiency and a lathyrogen. J Biol Chem. 1965; 240(9):3623-7. View

Kaye M, Silverman M . Calcium metabolism in chronic renal failure. J Lab Clin Med. 1965; 66(4):535-48. View

STANBURY S, LUMB G . Parathyroid function in chronic renal failure. A statistical survey of the plasma biochemistry in azotaemic renal osteodystrophy. Q J Med. 1966; 35(137):1-23. View

LEMANN Jr J, Litzow J, Lennon E . The effects of chronic acid loads in normal man: further evidence for the participation of bone mineral in the defense against chronic metabolic acidosis. J Clin Invest. 1966; 45(10):1608-14. PMC: 292842. DOI: 10.1172/JCI105467. View

Peck W, DIRKSEN T . The metabolism of bone tissue in vitro. Clin Orthop Relat Res. 1966; 48:243-65. View

Tanzer M, Monroe D, Gross J . Inhibition of collagen intermolecular cross-linking by thiosemicarbazide. Biochemistry. 1966; 5(6):1919-26. DOI: 10.1021/bi00870a019. View

Laitinen O . Parathyroid-induced changes in collagen and calcium metabolism in vivo. Endocrinology. 1967; 80(5):815-24. DOI: 10.1210/endo-80-5-815. View

Termine J, Posner A . Amorphous/crystalline interrelationships in bone mineral. Calcif Tissue Res. 1967; 1(1):8-23. DOI: 10.1007/BF02008070. View

10.

STANBURY S . Bone disease in uremia. Am J Med. 1968; 44(5):714-24. DOI: 10.1016/0002-9343(68)90253-2. View

11.

Mills B, BAVETTA L . Bone collagen dynamics. Clin Orthop Relat Res. 1968; 57:267-75. View

12.

Avioli L, Birge S, Lee S, Slatopolsky E . The metabolic fate of vitamin D3-3H in chronic renal failure. J Clin Invest. 1968; 47(10):2239-52. PMC: 297388. DOI: 10.1172/JCI105909. View

13.

Uitto J, Laitinen O . Relation of collagen metabolism to calcium metabolism in the bone. Acta Chem Scand. 1968; 22(3):1039-40. DOI: 10.3891/acta.chem.scand.22-1039. View

14.

Genuth S, VERTES V, LEONARDS J . Oral calcium absorption in patients with renal failure treated by chronic hemodialysis. Metabolism. 1969; 18(2):124-31. DOI: 10.1016/0026-0495(69)90106-1. View

15.

Flanagan B, Nichols Jr G . Bone matrix turnover and balance in vitro. I. The effects of parathyroid hormone and thyrocalcitonin. J Clin Invest. 1969; 48(4):595-606. PMC: 322265. DOI: 10.1172/JCI106018. View

16.

Deshmukh K, Nimni M . A defect in the intramolecular and intermolecular cross-linking of collagen caused by penicillamine. II. Functional groups involved in the interaction process. J Biol Chem. 1969; 244(7):1787-95. View

17.

Rojkind M, Gutierrez A . The binding of thiosemicarbazide to collagen in vro. Arch Biochem Biophys. 1969; 131(1):116-22. DOI: 10.1016/0003-9861(69)90111-8. View

18.

Canas F, Brnd J, NEUMAN W, TEREPKA A . Some effects of vitamin D 3 on collagen synthesis in rachitic chick cortical bone. Am J Physiol. 1969; 216(5):1092-6. DOI: 10.1152/ajplegacy.1969.216.5.1092. View

19.

Potts J, Reita R, Deftos L, Kaye M, Richardson J, Buckle R . Secondary hyperparathyroidism in chronic renal disease. Arch Intern Med. 1969; 124(4):408-12. View

20.

Avioli L, Scott S, Lee S, De Luca H . Intestinal calcium absorption: nature of defect in chronic renal disease. Science. 1969; 166(3909):1154-6. DOI: 10.1126/science.166.3909.1154. View