Mutagen Stability of Alkylation-sensitive Mutants of Bacillus Subtilis

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1972 Apr 1

PMID 4622905

Citations 11

Authors

T Hill

L Prakash

B Strauss

Affiliations

Soon will be listed here.

Abstract

A series of mutations of Bacillus subtilis, conferring sensitivity to methyl methanesulfonate (MMS), were transferred by transformation to a suppressible his(-) stock. The introduction of certain sensitivity mutations prevented the ultraviolet- or MMS-induced, but not the spontaneous, reversion of his(-) to his(+). Not all sensitivity mutations led to this resistance to mutagenesis; a strain with altered deoxyribonucleic acid (DNA) polymerase activity behaved almost normally with respect to its mutagen response, as did an excision-defective, ultraviolet-sensitive strain used as a control. One of the mutagen-stable strains responded to mutagenesis with nitrosomethylguanidine; another appeared stable even to this mutagen. All mutagen-stable strains had DNA polymerase and DNA ligase activity.

Citing Articles

Deoxyribonucleic Acid Repair in Bacillus subtilis: Development of Competent Cells into a Tester for Carcinogens.

Yasbin R, Miehl R Appl Environ Microbiol. 1980; 39(4):854-8.

PMID: 16345548 PMC: 291433. DOI: 10.1128/aem.39.4.854-858.1980.

Genetic and enzymic studies on the recombination process in Bacillus subtilis.

Mazza G, Fortunato A, Ferrari E, Canosi U, Falaschi A, Polsinelli M Mol Gen Genet. 1975; 136(1):9-30.

PMID: 16094963 DOI: 10.1007/BF00275445.

Misrepair mutagenesis in Myxococcus xanthus: induction of rifampicin-resistant mutants by N-methyl-N'-nitro-N-nitrosoguanidine and ultraviolet-irradiation.

Herdrich K, Grimm K Mol Gen Genet. 1981; 182(2):304-9.

PMID: 6793809 DOI: 10.1007/BF00269675.

Adaptive response of Bacillus subtilis to N-methyl-N'-nitro-N-nitrosoguanidine.

Hadden C, Foote R, Mitra S J Bacteriol. 1983; 153(2):756-62.

PMID: 6401705 PMC: 221694. DOI: 10.1128/jb.153.2.756-762.1983.

Lack of chemically induced mutation in repair-deficient mutants of yeast.

Prakash L Genetics. 1974; 78(4):1101-18.

PMID: 4376097 PMC: 1213240. DOI: 10.1093/genetics/78.4.1101.

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