Perinatal Development of 3-hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Rat Lung, Liver and Brain

Overview

Journal Lipids

Specialty Biochemistry

Date 1979 May 1

PMID 459709

Citations 3

Authors

G C Ness

J P Miller

M H Moffler

L S Woods

H B Harris

Affiliations

Soon will be listed here.

Abstract

The developmental pattern of microsomal 3-hydroxy-3-methylglutaryl coenzyme A reductase (EC 1.1.1.34), which catalyzes the rate-limiting step of cholesterol biosynthesis, was studied in lung, liver and brain of Sprague-Dawley rats. Each tissue exhibited a distinct pattern. Reductase activity in the fetal lung reached a peak at 19 days of gestation, which corresponds to the onset of active surfactant production. This observation is consistent with the suggestion that the fetal lung synthesizes all surfactant components including cholesterol. In the liver, reductase activity varied in a reciprocal fashion with serum cholesterol levels. The peak of brain reductase activity occurred at 3 days after birth at the onset of rapid brain growth despite rapidly rising serum cholesterol levels.

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References

ABEL L, LEVY B, Brodie B, KENDALL F . A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J Biol Chem. 1952; 195(1):357-66. View

Shapiro D, Nordstrom J, Mitschelen J, Rodwell V, Schimke R . Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. Biochim Biophys Acta. 1974; 370(2):369-77. DOI: 10.1016/0005-2744(74)90098-9. View

Nervi F, Weis H, Dietschy J . The kinetic characteristics of inhibition of hepatic cholesterogenesis by lipoproteins of intestinal origin. J Biol Chem. 1975; 250(11):4145-51. View

Avigan J, Bhathena S, Schreiner M . Control of sterol synthesis and of hydroxymethylglutaryl CoA reductase in skin fibroblasts grown from patients with homozygous type II hyperlipoproteinemia. J Lipid Res. 1975; 16(2):151-4. View

KANDUTSCH A, Chen H . Consequences of blocked sterol synthesis in cultured cells. DNA synthesis and membrane composition. J Biol Chem. 1977; 252(2):409-15. View

King R . The surfactant system of the lung. Fed Proc. 1974; 33(11):2238-47. View

Connor W, Johnston R, Lin D . Metabolism of cholesterol in the tissues and blood of the chick embryo. J Lipid Res. 1969; 10(4):388-94. View

Davison A . Brain sterol metabolism. Adv Lipid Res. 1965; 3:171-96. DOI: 10.1016/b978-1-4831-9939-9.50011-5. View

Gluck L, Chez R, KULOVICH M, HUTCHINSON D, NIEMANN W . Comparison of phospholipid indicators of fetal lung maturity in the amniotic fluid of the monkey (Macaca mulatta) and baboon (Papio papio). Am J Obstet Gynecol. 1974; 120(4):524-30. DOI: 10.1016/0002-9378(74)90631-0. View

10.

Chen H, Heiniger H, KANDUTSCH A . Relationship between sterol synthesis and DNA synthesis in phytohemagglutinin-stimulated mouse lymphocytes. Proc Natl Acad Sci U S A. 1975; 72(5):1950-4. PMC: 432666. DOI: 10.1073/pnas.72.5.1950. View

11.

Van Golde L . Metabolism of phospholipids in the lung. Am Rev Respir Dis. 1976; 114(5):977-1000. DOI: 10.1164/arrd.1976.114.5.977. View

12.

Shapiro D, Rodwell V . Regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol synthesis. J Biol Chem. 1971; 246(10):3210-6. View

13.

Ladbrooke B, Williams R, Chapman D . Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction. Biochim Biophys Acta. 1968; 150(3):333-40. DOI: 10.1016/0005-2736(68)90132-6. View

14.

Lee Y, LARDY H . INFLUENCE OF THYROID HORMONES ON L-ALPHA-GLYCEROPHOSPHATE DEHYDROGENASES AND OTHER DEHYDROGENASES IN VARIOUS ORGANS OF THE RAT. J Biol Chem. 1965; 240:1427-36. View

15.

Farrell P, Avery M . Hyaline membrane disease. Am Rev Respir Dis. 1975; 111(5):657-88. DOI: 10.1164/arrd.1975.111.5.657. View

16.

Ness G, Moffler M . Interference with the determination of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and its properties by a microsomal enzymic activity. Arch Biochem Biophys. 1978; 189(1):221-3. DOI: 10.1016/0003-9861(78)90135-2. View

17.

Batenburg J, LONGMORE W, Van Golde L . The synthesis of phosphatidylcholine by adult rat lung alveolar type II epithelial cells in primary culture. Biochim Biophys Acta. 1978; 529(1):160-70. DOI: 10.1016/0005-2760(78)90114-5. View

18.

McNamara D, QUACKENBUSH F, Rodwell V . Regulation of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase. Developmental pattern. J Biol Chem. 1972; 247(18):5805-10. View

19.

Edwards P, POPJAK G, Fogelman A, Edmond J . Control of 3-hydroxy-3-methylglutaryl coenzyme A reductase by endogenously synthesized sterols in vitro and in vivo. J Biol Chem. 1977; 252(3):1057-63. View

20.

Aragon M, Gimenez C, Valdivieso F, Mayor F . Hydroxymethylglutaryl-CoA reductase (NADPH) activity in rat brain during development. J Neurochem. 1978; 30(3):649-50. DOI: 10.1111/j.1471-4159.1978.tb07822.x. View