Hepatitis B E-antigen and Its Correlation with Other Serological Markers in Chimpanzees

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1979 May 1

PMID 457278

Citations 1

Authors

C M Ling

I K MUSHAHWAR

L R Overby

K R Berquist

J E MAYNARD

Affiliations

Soon will be listed here.

Abstract

Three chimpanzees experimentally infected with hepatitis B virus, and another three chimpanzees that were hepatitis surface antigen carriers, were studied for the presence of viral antigens and humoral immune responses. Quantitative analyses of hepatitis B surface and e-antigens in sequential serum samples at early acute stages revealed cyclic oscillations of these two antigens following a synchronous pattern. Similar analyses of anti-e-antigen and anti-hepatitis B core antigen antibodies from the three experimentally infected primates indicated that peak titers of these two antibodies occurred as surface antigen decreased to undetectable levels. Of the three surface-antigen carriers, two were positive for e-antigen and one was positive for e-antigen antibody for the entire course of surveillance (8, 9, and 22 months, respectively).

Citing Articles

Serological testing for hepatitis B in male homosexuals: special emphasis on hepatitis B e antigen and antibody by radioimmunoassay.

Murphy B, Schreeder M, MAYNARD J, Hadler S, Sheller M J Clin Microbiol. 1980; 11(3):301-3.

PMID: 6769950 PMC: 273386. DOI: 10.1128/jcm.11.3.301-303.1980.

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