Hepatitis B Antigens in Serum and Liver of Chimpanzees Acutely Infected with Hepatitis B Virus

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1975 Sep 1

PMID 1100525

Citations 16

Authors

K R Berquist

J M Peterson

B L Murphy

J W Ebert

J E MAYNARD

R H Purcell

Affiliations

Soon will be listed here.

Abstract

We report the temporal patterns of various immunohistological and serological parameters of acute self-limited hepatitis B virus infection of two chimpanzees, and we provide evidence that the synthesis of hepatitis B core antigen precedes that of hepatitis B surface antigen. Our data suggest that existence of a biphasic hepatitis B virus infection involving a hematogenous reinfection of the liver and indicate that recruitment of liver cells to produce hepatitis B virus may occur in a pattern consistent with a replicative cycle of about 8 days.

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References

Clark H, SHEPARD C . A DIALYSIS TECHNIQUE FOR PREPARING FLUORESCENT ANTIBODY. Virology. 1963; 20:642-4. DOI: 10.1016/0042-6822(63)90292-7. View

MAYNARD J, Berquist K, Krushak D, Purcell R . Experimental infection of chimpanzees with the virus of hepatitis B. Nature. 1972; 237(5357):514-5. DOI: 10.1038/237514a0. View

Almeida J, Rubenstein D, Stott E . New antigen-antibody system in Australia-antigen-positive hepatitis. Lancet. 1971; 2(7736):1225-7. DOI: 10.1016/s0140-6736(71)90543-5. View

Bradley D, MAYNARD J, Berquist K, Krushak D . Hepatitis B and serum DNA polymerase activities in chimpanzees. Nature. 1974; 251(5473):356-7. DOI: 10.1038/251356a0. View

Krugman S, Hoofnagle J, Gerety R, KAPLAN P, Gerin J . Viral hepatitis, type B, DNA polymerase activity and antibody to hepatitis B core antigen. N Engl J Med. 1974; 290(24):1331-5. DOI: 10.1056/NEJM197406132902401. View

Lander H, Holland P, Alter H, Chanock R, Purcell R . Antibody to hepatitis-associated antigen. Frequency and pattern of response as detected by radioimmunoprecipitation. JAMA. 1972; 220(8):1079-82. DOI: 10.1001/jama.220.8.1079. View

Purcell R, Walsh J, Holland P, Morrow A, Wood S, Chanock R . Seroepidemiological studies of transfusion-associated hepatitis. J Infect Dis. 1971; 123(4):406-13. DOI: 10.1093/infdis/123.4.406. View

Barker L, Chisari F, McGrath P, Dalgard D, KIRSCHSTEIN R, Almeida J . Transmission of type B viral hepatitis to chimpanzees. J Infect Dis. 1973; 127(6):648-62. DOI: 10.1093/infdis/127.6.648. View

Krugman S, GILES J, Hammond J . Infectious hepatitis. Evidence for two distinctive clinical, epidemiological, and immunological types of infection. JAMA. 1967; 200(5):365-73. DOI: 10.1001/jama.200.5.365. View

10.

NOWOSLAWSKI A, BRZOSKO W, Madalinski K, Krawczynski K . Cellular localisation of Australia antigen in the liver of patients with lymphoproliferative disorders. Lancet. 1970; 1(7645):494-8. DOI: 10.1016/s0140-6736(70)91580-1. View

11.

Edgington T, Ritt D . Intrahepatic expression of serum hepatitis virus-associated antigens. J Exp Med. 1971; 134(4):871-85. PMC: 2139001. DOI: 10.1084/jem.134.4.871. View

12.

Akeyama T, Kamada T, Koyama M, Abe H . Distribution patterns of hepatitis B antigen in the liver. Immunofluorescence studies. Arch Pathol. 1974; 98(4):252-6. View

13.

Blumberg B, Gerstley B, HUNGERFORD D, London W, Sutnick A . A serum antigen (Australia antigen) in Down's syndrome, leukemia, and hepatitis. Ann Intern Med. 1967; 66(5):924-31. DOI: 10.7326/0003-4819-66-5-924. View

14.

Irwin Jr G, Hierholzer Jr W, Cimis R, McCOLLUM R . Delayed hypersensitivity in hepatitis B: clinical correlates of in vitro production of migration inhibition factor. J Infect Dis. 1974; 130(6):580-7. DOI: 10.1093/infdis/130.6.580. View

15.

Millman I, Zavatone V, Gerstley B, Blumberg B . Australia antigen detected in the nuclei of liver cells of patients with viral hepatitis by the fluorescent antibody technic. Nature. 1969; 222(5189):181-4. DOI: 10.1038/222181b0. View

16.

Blumberg B, Sutnick A, London W . Hepatitis and leukemia: their relation to Australia antigen. Bull N Y Acad Med. 1968; 44(12):1566-86. PMC: 1750308. View

17.

Allison A, Blumberg B . An isoprecipitation reaction distinguishing human serum-protein types. Lancet. 1961; 1(7178):634-7. DOI: 10.1016/s0140-6736(61)91654-3. View